Stefanos Tyrovolas1, Ai Koyanagi2, Beatriz Olaya2, Jose Luis Ayuso-Mateos3, Marta Miret3, Somnath Chatterji4, Beata Tobiasz-Adamczyk5, Seppo Koskinen6, Matilde Leonardi7, Josep Maria Haro2. 1. Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, Dr Antoni Pujades, 42, 08830 Sant Boi de Llobregat, Barcelona, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Monforte de Lemos 3-5. Pabellón 11, 28029 Madrid, Spain. Electronic address: s.tyrovolas@pssjd.org. 2. Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, Dr Antoni Pujades, 42, 08830 Sant Boi de Llobregat, Barcelona, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Monforte de Lemos 3-5. Pabellón 11, 28029 Madrid, Spain. 3. Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Monforte de Lemos 3-5. Pabellón 11, 28029 Madrid, Spain; Department of Psychiatry, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria Princesa (IP), Hospital Universitario la Princesa, Madrid, Spain. 4. Department of Health Statistics and Information Systems, World Health Organization, Geneva, Switzerland. 5. Department of Medical Sociology, Jagiellonian University Medical College, Krakow, Poland. 6. National Institute for Health and Welfare, Helsinki, Finland. 7. Neurology, Public Health and Disability Unit, Neurological Institute "Carlo Besta" Foundation IRCCS (Istituto di ricovero e cura a carattere scientifico), Milan, Italy.
Abstract
BACKGROUND: The aim of this study was to evaluate the association of sarcopenia and sarcopenic obesity with disability among older adults (≥65years old) in nine high-, middle- and low-income countries from Asia, Africa, Europe, and Latin America. METHODS: Data were available for 53,289 people aged ≥18years who participated in the Collaborative Research on Ageing in Europe (COURAGE) survey conducted in Finland, Poland, and Spain, and the WHO Study on global AGEing and adult health (SAGE) survey conducted in China, Ghana, India, Mexico, Russia, and South Africa, between 2007 and 2012. Skeletal muscle mass, skeletal muscle mass index, and percent body fat were calculated with specific population formulas. Sarcopenia and sarcopenic obesity were defined by specific cut-offs used in previous studies. Disability was assessed with the WHODAS 2.0 score (range 0-100) with higher scores corresponding to higher levels of disability. Multivariable linear regression analysis was conducted with disability as the outcome. RESULTS: The analytical sample consisted of 18,363 people (males; n=8116, females; n=10247) aged ≥65years with mean (SD) age 72.9 (11.1) years. In the fully-adjusted overall analysis, sarcopenic obesity was associated with greater levels of disability [b-coefficient 3.01 (95% CI 1.14-4.88)]. In terms of country-wise analyses, sarcopenia was associated with higher WHODAS 2.0 scores in China [b-coefficient 4.56 (95% CI: 3.25-5.87)], Poland [b-coefficient 6.66 (95% CI: 2.17-11.14)], Russia [b-coefficient 5.60 (95% CI: 2.03-9.16)], and South Africa [b-coefficient 7.75 (95% CI: 1.56-13.94)]. CONCLUSIONS: Prevention of muscle mass decline may contribute to reducing the global burden of disability.
BACKGROUND: The aim of this study was to evaluate the association of sarcopenia and sarcopenic obesity with disability among older adults (≥65years old) in nine high-, middle- and low-income countries from Asia, Africa, Europe, and Latin America. METHODS: Data were available for 53,289 people aged ≥18years who participated in the Collaborative Research on Ageing in Europe (COURAGE) survey conducted in Finland, Poland, and Spain, and the WHO Study on global AGEing and adult health (SAGE) survey conducted in China, Ghana, India, Mexico, Russia, and South Africa, between 2007 and 2012. Skeletal muscle mass, skeletal muscle mass index, and percent body fat were calculated with specific population formulas. Sarcopenia and sarcopenic obesity were defined by specific cut-offs used in previous studies. Disability was assessed with the WHODAS 2.0 score (range 0-100) with higher scores corresponding to higher levels of disability. Multivariable linear regression analysis was conducted with disability as the outcome. RESULTS: The analytical sample consisted of 18,363 people (males; n=8116, females; n=10247) aged ≥65years with mean (SD) age 72.9 (11.1) years. In the fully-adjusted overall analysis, sarcopenic obesity was associated with greater levels of disability [b-coefficient 3.01 (95% CI 1.14-4.88)]. In terms of country-wise analyses, sarcopenia was associated with higher WHODAS 2.0 scores in China [b-coefficient 4.56 (95% CI: 3.25-5.87)], Poland [b-coefficient 6.66 (95% CI: 2.17-11.14)], Russia [b-coefficient 5.60 (95% CI: 2.03-9.16)], and South Africa [b-coefficient 7.75 (95% CI: 1.56-13.94)]. CONCLUSIONS: Prevention of muscle mass decline may contribute to reducing the global burden of disability.
Authors: Robert D Boutin; Sara Bamrungchart; Cyrus P Bateni; Daniel P Beavers; Kristen M Beavers; John P Meehan; Leon Lenchik Journal: AJR Am J Roentgenol Date: 2017-03-07 Impact factor: 3.959
Authors: Victoria E Sanborn; Mary-Beth Spitznagel; Ross Crosby; Kristine Steffen; James Mitchell; John Gunstad Journal: Surg Obes Relat Dis Date: 2018-06-21 Impact factor: 4.734
Authors: Samuel T H Chew; Geetha Kayambu; Charles Chin Han Lew; Tze Pin Ng; Fangyi Ong; Jonathan Tan; Ngiap Chuan Tan; Shuen-Loong Tham Journal: BMC Geriatr Date: 2021-05-17 Impact factor: 3.921
Authors: Lee Smith; Louis Jacob; Yvonne Barnett; Laurie T Butler; Jae Il Shin; Guillermo F López-Sánchez; Pinar Soysal; Nicola Veronese; Josep Maria Haro; Ai Koyanagi Journal: Nutrients Date: 2021-05-31 Impact factor: 5.717