Feifei Chen1, Yunlong Xia1, Ying Liu1, Yutao Zhang1, Wei Song1, Yang Zhong2, Lianjun Gao1, Yan Jin3, Shijun Li3, Yinong Jiang4, Yanzong Yang5. 1. Department of Cardiology, First Affiliated Hospital of Dalian Medical University, No. 193, Lianhe Road, Shahekou District, 116000 Dalian, China. 2. Department of Cardiology, The Fifth People's Hospital of Dalian, No. 890, Huanghe Road, Shahekou District, 116000 Dalian, China. 3. Department of Clinic Laboratory, First Affiliated Hospital of Dalian Medical University, No. 193, Lianhe Road, Shahekou District, 116000 Dalian, China. 4. Department of Cardiology, First Affiliated Hospital of Dalian Medical University, No. 193, Lianhe Road, Shahekou District, 116000 Dalian, China. Electronic address: jiangyn64510@yahoo.com.cn. 5. Department of Cardiology, First Affiliated Hospital of Dalian Medical University, No. 193, Lianhe Road, Shahekou District, 116000 Dalian, China. Electronic address: yyzheart@126.com.
Abstract
BACKGROUND: NPPA mutations/polymorphisms were associated with atrial fibrillation (AF), and plasma proatrial natriuretic peptide (proANP) concentrations were increased in AF patients. Corin, as a transmembrane protease that processes proANP in the heart, may play a potential role in AF. METHODS: To test whether corin concentrations are altered in AF patients, we used ELISA to measure corin and N-terminal proANP (NT-proANP) concentrations in plasma samples from control (n=127) and AF patients (n=141), including paroxysmal AF (PAF, n=83) and persistent AF (PeAF, n=58). RESULTS: In patients with AF, plasma corin concentrations were 1209±510pg/ml, which were significantly higher than in the controls (973±528pg/ml, P<0.001). The increased plasma corin concentrations were found in both male and female patients. Plasma NT-proANP concentrations in AF patients were 3.1±2.42nmol/l, which were higher than in the controls (1.77±1.04nmol/l, P<0.001). Gender (P=0.003), weight (P=0.016) and PR interval (P=0.028) were independent predictors of plasma corin concentrations in AF patients. A positive correlation was found between corin concentrations and left atrial diameter/PR interval in AF patients. CONCLUSION: High plasma corin concentrations in AF patients suggest that corin may play an important role in the pathology of AF.
BACKGROUND:NPPA mutations/polymorphisms were associated with atrial fibrillation (AF), and plasma proatrial natriuretic peptide (proANP) concentrations were increased in AFpatients. Corin, as a transmembrane protease that processes proANP in the heart, may play a potential role in AF. METHODS: To test whether corin concentrations are altered in AFpatients, we used ELISA to measure corin and N-terminal proANP (NT-proANP) concentrations in plasma samples from control (n=127) and AFpatients (n=141), including paroxysmal AF (PAF, n=83) and persistent AF (PeAF, n=58). RESULTS: In patients with AF, plasma corin concentrations were 1209±510pg/ml, which were significantly higher than in the controls (973±528pg/ml, P<0.001). The increased plasma corin concentrations were found in both male and female patients. Plasma NT-proANP concentrations in AFpatients were 3.1±2.42nmol/l, which were higher than in the controls (1.77±1.04nmol/l, P<0.001). Gender (P=0.003), weight (P=0.016) and PR interval (P=0.028) were independent predictors of plasma corin concentrations in AFpatients. A positive correlation was found between corin concentrations and left atrial diameter/PR interval in AFpatients. CONCLUSION: High plasma corin concentrations in AFpatients suggest that corin may play an important role in the pathology of AF.
Authors: Dong Wang; Inna P Gladysheva; Ryan D Sullivan; Tai-Hwang M Fan; Radhika M Mehta; Ranjana Tripathi; Yao Sun; Guy L Reed Journal: PLoS One Date: 2018-09-07 Impact factor: 3.240