Sabah Gheddouchi1, Nassima Mokhtari-Soulimane2, Hafida Merzouk1, Fadia Bekhti1, Fayçal Soulimane3, Baya Guermouche1, Abderrahim Meziane Tani3, Michel Narce4. 1. Laboratory of Physiology, Physiopathology and Biochemistry of Nutrition(PPABIONUT), Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, Abou-Bekr Belkaïd University, Tlemcen 13000, Algeria. 2. Laboratory of Physiology, Physiopathology and Biochemistry of Nutrition(PPABIONUT), Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, Abou-Bekr Belkaïd University, Tlemcen 13000, Algeria. Electronic address: nassima_amel@yahoo.fr. 3. Cardiology Department of Tlemcen University Hospital Center, Tlemcen 13000, Algeria. 4. INSERM UMR 866, "Lipids Nutrition Cancer", Faculty of Life, Earth, and Environment Sciences, University of Burgundy, Dijon 21000, France.
Abstract
OBJECTIVE: The present study was undertaken to evaluate the variation of the oxidative/nitrosative stress status in a population of subjects; with acute coronary syndrome (ACS), and examine its possible implication in plaque rupture which is the main mechanism in the pathophysiology of ACS. PATIENTS AND METHODS: We made this study on 50 men with ACS and 50 age and sex matched healthy controls. Nitrosative/oxidative stress markers including; nitric oxide, superoxide anion levels, superoxide dismutase (SOD) activity and peroxynitrite levels were evaluated in blood samples of patients and controls. RESULTS: Compared with healthy subjects, coronary patients had significantly higher nitric oxide, peroxynitrite and superoxide anion concentrations in both plasma and erythrocytes associated to significant decrease of SOD activity. Erythrocytes peroxynitrite concentration was negatively correlated with the antioxidant enzyme activity (SOD). CONCLUSION: Our results show a significant accumulation of both intracellular and plasma pro-oxidants with a concomitant decrease in the SOD scavenging activity in ACS patients. Both seem to be associated with plaque rupture and ischemia observed in ACS.
OBJECTIVE: The present study was undertaken to evaluate the variation of the oxidative/nitrosative stress status in a population of subjects; with acute coronary syndrome (ACS), and examine its possible implication in plaque rupture which is the main mechanism in the pathophysiology of ACS. PATIENTS AND METHODS: We made this study on 50 men with ACS and 50 age and sex matched healthy controls. Nitrosative/oxidative stress markers including; nitric oxide, superoxide anion levels, superoxide dismutase (SOD) activity and peroxynitrite levels were evaluated in blood samples of patients and controls. RESULTS: Compared with healthy subjects, coronary patients had significantly higher nitric oxide, peroxynitrite and superoxide anion concentrations in both plasma and erythrocytes associated to significant decrease of SOD activity. Erythrocytes peroxynitrite concentration was negatively correlated with the antioxidant enzyme activity (SOD). CONCLUSION: Our results show a significant accumulation of both intracellular and plasma pro-oxidants with a concomitant decrease in the SOD scavenging activity in ACS patients. Both seem to be associated with plaque rupture and ischemia observed in ACS.
Authors: Francisco Visiedo; Celeste Santos-Rosendo; Rosa M Mateos-Bernal; M Del Mar Gil-Sánchez; Fernando Bugatto; Manuel Aguilar-Diosdado; Carmen Segundo; Cristina López-Tinoco Journal: Oxid Med Cell Longev Date: 2017-03-16 Impact factor: 6.543
Authors: Laurent Chatre; Aurélien Ducat; Frank T Spradley; Ana C Palei; Christiane Chéreau; Betty Couderc; Kamryn C Thomas; Anna R Wilson; Lorena M Amaral; Irène Gaillard; Céline Méhats; Isabelle Lagoutte; Sébastien Jacques; Francisco Miralles; Frédéric Batteux; Joey P Granger; Miria Ricchetti; Daniel Vaiman Journal: Redox Biol Date: 2022-07-30 Impact factor: 10.787