Literature DB >> 26046756

Can Metabolic Mechanisms of Stem Cell Maintenance Explain Aging and the Immortal Germline?

Hans-Willem Snoeck1.   

Abstract

The mechanisms underlying the aging process are not understood. Even tissues endowed with somatic stem cells age while the germline appears immortal. I propose that this paradox may be explained by the pervasive use of glycolysis by somatic stem cells as opposed to the predominance of mitochondrial respiration in gametes.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26046756      PMCID： PMC5797848          DOI： 10.1016/j.stem.2015.04.021

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  10 in total

Review 1.  DNA-damage response in tissue-specific and cancer stem cells.

Authors:  Cedric Blanpain; Mary Mohrin; Panagiota A Sotiropoulou; Emmanuelle Passegué
Journal:  Cell Stem Cell       Date:  2011-01-07       Impact factor: 24.633

Review 2.  The germline stem cell niche unit in mammalian testes.

Authors:  Jon M Oatley; Ralph L Brinster
Journal:  Physiol Rev       Date:  2012-04       Impact factor: 37.312

Review 3.  Aging of the hematopoietic system.

Authors:  Hans-Willem Snoeck
Journal:  Curr Opin Hematol       Date:  2013-07       Impact factor: 3.284

Review 4.  Metabolic requirements for the maintenance of self-renewing stem cells.

Authors:  Keisuke Ito; Toshio Suda
Journal:  Nat Rev Mol Cell Biol       Date:  2014-04       Impact factor: 94.444

5.  Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging.

Authors:  Gudmundur L Norddahl; Cornelis J Pronk; Martin Wahlestedt; Gerd Sten; Jens M Nygren; Amol Ugale; Mikael Sigvardsson; David Bryder
Journal:  Cell Stem Cell       Date:  2011-05-06       Impact factor: 24.633

6.  A mitochondrial bioenergetic etiology of disease.

Authors:  Douglas C Wallace
Journal:  J Clin Invest       Date:  2013-04-01       Impact factor: 14.808

Review 7.  The costs of being male: are there sex-specific effects of uniparental mitochondrial inheritance?

Authors:  Madeleine Beekman; Damian K Dowling; Duur K Aanen
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2014-07-05       Impact factor: 6.237

Review 8.  Mitochondrial quality control: a matter of life and death for neurons.

Authors:  Elena I Rugarli; Thomas Langer
Journal:  EMBO J       Date:  2012-02-21       Impact factor: 11.598

Review 9.  Physiological roles of mitochondrial reactive oxygen species.

Authors:  Laura A Sena; Navdeep S Chandel
Journal:  Mol Cell       Date:  2012-10-26       Impact factor: 17.970

Review 10.  Understanding the odd science of aging.

Authors:  Thomas B L Kirkwood
Journal:  Cell       Date:  2005-02-25       Impact factor: 41.582
  10 in total
  5 in total

1.  The Antiaging Gene Klotho Regulates Proliferation and Differentiation of Adipose-Derived Stem Cells.

Authors:  Jun Fan; Zhongjie Sun
Journal:  Stem Cells       Date:  2016-02-26       Impact factor: 6.277

2.  The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts.

Authors:  Vedad Delic; Kenyaria Noble; Sandra Zivkovic; Tam-Anh Phan; Christian Reynes; Yumeng Zhang; Oluwakemi Phillips; Charles Claybaker; Yen Ta; Vinh B Dinh; Josean Cruz; Tomas A Prolla; Patrick C Bradshaw
Journal:  Biol Open       Date:  2018-11-16       Impact factor: 2.422

Review 3.  Impacts of cannabinoid epigenetics on human development: reflections on Murphy et. al. 'cannabinoid exposure and altered DNA methylation in rat and human sperm' epigenetics 2018; 13: 1208-1221.

Authors:  Albert Stuart Reece; Gary Kenneth Hulse
Journal:  Epigenetics       Date:  2019-07-11       Impact factor: 4.528

4.  Informational Theory of Aging: The Life Extension Method Based on the Bone Marrow Transplantation.

Authors:  Alexey V Karnaukhov; Elena V Karnaukhova; Larisa A Sergievich; Natalia A Karnaukhova; Elena V Bogdanenko; Irina A Manokhina; Valery N Karnaukhov
Journal:  J Biophys       Date:  2015-09-30

Review 5.  Fate of Hematopoiesis During Aging. What Do We Really Know, and What are its Implications?

Authors:  Hal E Broxmeyer; Yan Liu; Reuben Kapur; Christie M Orschell; Arafat Aljoufi; James P Ropa; Thao Trinh; Sarah Burns; Maegan L Capitano
Journal:  Stem Cell Rev Rep       Date:  2020-11-03       Impact factor: 5.739
  5 in total

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