Yoshinori Kawabata1, Yoshihiko Shimizu1, Eishin Hoshi2, Kazumi Murai2, Tetsu Kanauchi3, Kazuyoshi Kurashima4, Yutaka Sugita4. 1. Division of Diagnostic Pathology, Saitama Prefectural Cardiovascular and Respiratory Centre, Kumagaya city, Japan. 2. Department of Thoracic Surgery, Saitama Prefectural Cardiovascular and Respiratory Centre, Kumagaya city, Japan. 3. Department of Radiology, Saitama Prefectural Cardiovascular and Respiratory Centre, Kumagaya city, Japan. 4. Department of Pulmonary Medicine, Saitama Prefectural Cardiovascular and Respiratory Centre, Kumagaya city, Japan.
Abstract
AIMS: We hypothesized that asbestos exposure increases the incidence of macroscopically visible and histologically confirmed usual interstitial pneumonia (histological UIP). METHODS AND RESULTS: We retrospectively examined 1718 cases (1202 males; mean age 66.7 years) who underwent lobectomy for resection of pleuropulmonary tumours. Objective markers for asbestos exposure included: the presence of malignant pleural mesothelioma, the presence of pleural plaques (PPs) and asbestos bodies in the histological specimen. Risk factors for histological UIP were examined. Two separate groups were studied: 183 with asbestos exposure, and 239 with histological UIP. The 183 cases with asbestos exposure had higher rates of positive occupational history and histological UIP (31%) than the remaining 1535. Among the asbestos-exposed group, small numbers of asbestos bodies were found in histological specimens of 21 cases of histological UIP. PPs and asbestos bodies were more frequent in the 239 patients with histological UIP than in the remaining 1479 UIP-negative patients. Multivariate analysis showed that asbestos exposure, especially positivity for asbestos bodies, that does not meet the current criteria for asbestosis increases the risk of histological UIP (P < 0.0001). CONCLUSIONS: Asbestos exposure causes asbestosis and increases the incidence of histological UIP.
AIMS: We hypothesized that asbestos exposure increases the incidence of macroscopically visible and histologically confirmed usual interstitial pneumonia (histological UIP). METHODS AND RESULTS: We retrospectively examined 1718 cases (1202 males; mean age 66.7 years) who underwent lobectomy for resection of pleuropulmonary tumours. Objective markers for asbestos exposure included: the presence of malignant pleural mesothelioma, the presence of pleural plaques (PPs) and asbestos bodies in the histological specimen. Risk factors for histological UIP were examined. Two separate groups were studied: 183 with asbestos exposure, and 239 with histological UIP. The 183 cases with asbestos exposure had higher rates of positive occupational history and histological UIP (31%) than the remaining 1535. Among the asbestos-exposed group, small numbers of asbestos bodies were found in histological specimens of 21 cases of histological UIP. PPs and asbestos bodies were more frequent in the 239 patients with histological UIP than in the remaining 1479 UIP-negative patients. Multivariate analysis showed that asbestos exposure, especially positivity for asbestos bodies, that does not meet the current criteria for asbestosis increases the risk of histological UIP (P < 0.0001). CONCLUSIONS:Asbestos exposure causes asbestosis and increases the incidence of histological UIP.
Authors: Eduardo Algranti; Cézar Akiyoshi Saito; Diego Rodrigues Mendonça E Silva; Ana Paula Scalia Carneiro; Marco Antonio Bussacos Journal: J Bras Pneumol Date: 2017 Nov-Dec Impact factor: 2.624