Literature DB >> 26046583

Downregulation of HOXC6 in Serous Ovarian Cancer.

David L Tait1, Zahra Bahrani-Mostafavi, C Greer Vestal, Christine Richardson, M Taghi Mostafavi.   

Abstract

Homeobox (HOX) genes encode transcription factors critical to morphogenesis and cell differentiation. Although dysregulation of several HOX genes in ovarian cancer has been reported, little is known about HOXC6 expression in epithelial ovarian cancer. In this report, analysis of laser capture microdissected samples determined HOXC6 expression patterns in normal versus malignant serous ovarian carcinoma tissues. HOXC6 protein was quantified by ELISA in parallel serum samples and further validated in a larger cohort of serum samples collected from women with and without serous ovarian carcinoma. These data demonstrate significant downregulation of HOXC6 in serous ovarian cancer.

Entities:  

Keywords:  Biomarker discovery; HOXC6; Homeobox genes; Serous ovarian cancer

Mesh：

Substances：

Year:  2015        PMID： 26046583     DOI： 10.3109/07357907.2015.1041641

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  6 in total

1.  Homeobox C9 suppresses Beclin1-mediated autophagy in glioblastoma by directly inhibiting the transcription of death-associated protein kinase 1.

Authors:  Fan Xuan; Mengying Huang; Wen Liu; Hanfei Ding; Liqun Yang; Hongjuan Cui
Journal:  Neuro Oncol       Date:  2015-11-17       Impact factor: 12.300

2.  Dysregulation of AKT3 along with a small panel of mRNAs stratifies high-grade serous ovarian cancer from both normal epithelia and benign tumor tissues.

Authors:  Pourya Naderi Yeganeh; Christine Richardson; Zahra Bahrani-Mostafavi; David L Tait; M Taghi Mostafavi
Journal:  Genes Cancer       Date:  2017-11

3.  Potential role of the HOXD8 transcription factor in cisplatin resistance and tumour metastasis in advanced epithelial ovarian cancer.

Authors:  PengMing Sun; YiYi Song; DaBin Liu; GuiFen Liu; XiaoDan Mao; BinHua Dong; Elena Ioana Braicu; Jalid Sehouli
Journal:  Sci Rep       Date:  2018-09-07       Impact factor: 4.379

4.  HOXC6 promotes migration, invasion and proliferation of esophageal squamous cell carcinoma cells via modulating expression of genes involved in malignant phenotypes.

Authors:  Li Tang; Yong Cao; Xueqin Song; Xiaoyan Wang; Yan Li; Minglan Yu; Mingying Li; Xu Liu; Fang Huang; Feng Chen; Haisu Wan
Journal:  PeerJ       Date:  2019-03-14       Impact factor: 2.984

5.  Overexpression of HOXC6 promotes cell proliferation and migration via MAPK signaling and predicts a poor prognosis in glioblastoma.

Authors:  PengYu Yang; Wei Kang; YaWen Pan; XianJun Zhao; Lei Duan
Journal:  Cancer Manag Res       Date:  2019-09-03       Impact factor: 3.989

6.  Dysregulated expression of homeobox family genes may influence survival outcomes of patients with epithelial ovarian cancer: analysis of data from The Cancer Genome Atlas.

Authors:  Kyung Jin Eoh; Hee Jung Kim; Jung-Yun Lee; Eun Ji Nam; Sunghoon Kim; Sang Wun Kim; Young Tae Kim
Journal:  Oncotarget       Date:  2017-08-01
  6 in total

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