| Literature DB >> 26046495 |
R Vikneswaran1, Muhamad Syamir Syafiq2, Naser Eltaher Eltayeb3, Mohd Naqiuddin Kamaruddin2, S Ramesh4, R Yahya5.
Abstract
Copper ion recognition and DNA interaction of a newly synthesized fluorescent Schiff base (HPyETSC) were investigated using UV-vis and fluorescent spectroscopy. Examination using these two techniques revealed that the detection of copper by HPyETSC is highly sensitive and selective, with a detection limit of 0.39 μm and the mode of interaction between HPyETSC and DNA is electrostatic, with a binding constant of 8.97×10(4) M(-1). Furthermore, gel electrophoresis studies showed that HPyETSC exhibited nuclease activity through oxidative pathway.Entities:
Keywords: Chemical nucleases; Chemosensor; DNA binding; Fluorescent; Thiosemicarbazone
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Year: 2015 PMID： 26046495 DOI： 10.1016/j.saa.2015.05.087
Source DB: PubMed Journal: Spectrochim Acta A Mol Biomol Spectrosc ISSN： 1386-1425 Impact factor: 4.098