Lizandra Jimenez, Sangeeta K Jayakar, Thomas J Ow, Jeffrey E Segall1. 1. From the Departments of Pathology (Mss Jimenez and Jayakar, and Drs Ow and Segall) and Anatomy and Structural Biology (Mss Jimenez and Jayakar, and Dr Segall), Albert Einstein College of Medicine, Bronx, New York.
Abstract
CONTEXT: The highly invasive properties demonstrated by head and neck squamous cell carcinoma (HNSCC) are often associated with locoregional recurrence and lymph node metastasis in patients and is a key factor leading to an expected 5-year survival rate of approximately 50% for patients with advanced disease. It is important to understand the features and mediators of HNSCC invasion so that new treatment approaches can be developed. OBJECTIVES: To provide an overview of the characteristics, mediators, and mechanisms of HNSCC invasion. DATA SOURCES: A literature review of peer-reviewed articles in PubMed on HNSCC invasion. CONCLUSIONS: Histologic features of HNSCC tumors can help predict prognosis and influence clinical treatment decisions. Cell surface receptors, signaling pathways, proteases, invadopodia function, epithelial-mesenchymal transition, microRNAs, and tumor microenvironment are all involved in the regulation of the invasive behavior of HNSCC cells. Identifying effective HNSCC invasion inhibitors has the potential to improve outcomes for patients by reducing the rate of spread and increasing responsiveness to chemoradiation.
CONTEXT: The highly invasive properties demonstrated by head and neck squamous cell carcinoma (HNSCC) are often associated with locoregional recurrence and lymph node metastasis in patients and is a key factor leading to an expected 5-year survival rate of approximately 50% for patients with advanced disease. It is important to understand the features and mediators of HNSCC invasion so that new treatment approaches can be developed. OBJECTIVES: To provide an overview of the characteristics, mediators, and mechanisms of HNSCC invasion. DATA SOURCES: A literature review of peer-reviewed articles in PubMed on HNSCC invasion. CONCLUSIONS: Histologic features of HNSCC tumors can help predict prognosis and influence clinical treatment decisions. Cell surface receptors, signaling pathways, proteases, invadopodia function, epithelial-mesenchymal transition, microRNAs, and tumor microenvironment are all involved in the regulation of the invasive behavior of HNSCC cells. Identifying effective HNSCC invasion inhibitors has the potential to improve outcomes for patients by reducing the rate of spread and increasing responsiveness to chemoradiation.
Authors: Sangeeta K Jayakar; Olivier Loudig; Margaret Brandwein-Gensler; Ryung S Kim; Thomas J Ow; Berrin Ustun; Thomas M Harris; Michael B Prystowsky; Geoffrey Childs; Jeffrey E Segall; Thomas J Belbin Journal: Am J Pathol Date: 2017-07-24 Impact factor: 4.307
Authors: T H Hui; W C Cho; H W Fong; M Yu; K W Kwan; K C Ngan; K H Wong; Y Tan; S Yao; H Jiang; Z Gu; Y Lin Journal: J R Soc Interface Date: 2019-06-05 Impact factor: 4.118
Authors: Susan R Mallery; Daren Wang; Brian Santiago; Ping Pei; Caroline Bissonnette; Jayanetti Asiri Jayawardena; Steven P Schwendeman; Richard Spinney; James Lang Journal: Mol Cancer Ther Date: 2019-09-12 Impact factor: 6.261
Authors: Lindsey E Romick-Rosendale; Elizabeth E Hoskins; Lisa M Privette Vinnedge; Grant D Foglesong; Marion G Brusadelli; S Steven Potter; Kakajan Komurov; Samantha A Brugmann; Paul F Lambert; Randall J Kimple; Elizabeth L Virts; Helmut Hanenberg; Maura L Gillison; Susanne I Wells Journal: Clin Cancer Res Date: 2015-11-24 Impact factor: 12.531
Authors: Yang Zheng; Zhao Wang; Xu Ding; Wei Zhang; Gang Li; Laikui Liu; Heming Wu; Wenyi Gu; Yunong Wu; Xiaomeng Song Journal: Cancer Cell Int Date: 2018-01-08 Impact factor: 5.722