Literature DB >> 26046078

Reducing affinity of αvβ8 interactions with latent TGFβ: dialling down fibrosis.

Amanda L Tatler1, Gisli Jenkins1.   

Abstract

Entities:  

Year:  2015        PMID： 26046078      PMCID： PMC4437960          DOI： 10.3978/j.issn.2305-5839.2015.02.18

Source DB:  PubMed          Journal:  Ann Transl Med        ISSN： 2305-5839


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  20 in total

1.  Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice.

Authors:  Andrew C Melton; Samantha L Bailey-Bucktrout; Mark A Travis; Brian T Fife; Jeffrey A Bluestone; Dean Sheppard
Journal:  J Clin Invest       Date:  2010-11-22       Impact factor: 14.808

2.  Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice.

Authors:  Mark A Travis; Boris Reizis; Andrew C Melton; Emma Masteller; Qizhi Tang; John M Proctor; Yanli Wang; Xin Bernstein; Xiaozhu Huang; Louis F Reichardt; Jeffrey A Bluestone; Dean Sheppard
Journal:  Nature       Date:  2007-08-12       Impact factor: 49.962

3.  Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts.

Authors:  Yoshihide Asano; Hironobu Ihn; Kenichi Yamane; Masatoshi Jinnin; Yoshihiro Mimura; Kunihiko Tamaki
Journal:  J Immunol       Date:  2005-12-01       Impact factor: 5.422

4.  Latent TGF-β structure and activation.

Authors:  Minlong Shi; Jianghai Zhu; Rui Wang; Xing Chen; Lizhi Mi; Thomas Walz; Timothy A Springer
Journal:  Nature       Date:  2011-06-15       Impact factor: 49.962

5.  Induction of heart valve lesions by small-molecule ALK5 inhibitors.

Authors:  Mark J Anderton; Howard R Mellor; Alex Bell; Claire Sadler; Martin Pass; Steve Powell; Samantha J Steele; Ruth R A Roberts; Annabelle Heier
Journal:  Toxicol Pathol       Date:  2011-08-22       Impact factor: 1.902

6.  Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.

Authors:  R Gisli Jenkins; Xiao Su; George Su; Christopher J Scotton; Eric Camerer; Geoffrey J Laurent; George E Davis; Rachel C Chambers; Michael A Matthay; Dean Sheppard
Journal:  J Clin Invest       Date:  2006-05-18       Impact factor: 14.808

7.  The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.

Authors:  J S Munger; X Huang; H Kawakatsu; M J Griffiths; S L Dalton; J Wu; J F Pittet; N Kaminski; C Garat; M A Matthay; D B Rifkin; D Sheppard
Journal:  Cell       Date:  1999-02-05       Impact factor: 41.582

8.  Tryptase activates TGFbeta in human airway smooth muscle cells via direct proteolysis.

Authors:  Amanda L Tatler; Joanne Porte; Alan Knox; Gisli Jenkins; Linhua Pang
Journal:  Biochem Biophys Res Commun       Date:  2008-03-24       Impact factor: 3.575

9.  Inhibition of ALK5 signaling induces physeal dysplasia in rats.

Authors:  Kendall Frazier; Roberta Thomas; Marshall Scicchitano; Rosanna Mirabile; Rogely Boyce; Dawn Zimmerman; Eugene Grygielko; James Nold; Anne-Charlotte DeGouville; Stephane Huet; Nicholas Laping; Francoise Gellibert
Journal:  Toxicol Pathol       Date:  2007-02       Impact factor: 1.902

10.  The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1.

Authors:  Dezhi Mu; Stephanie Cambier; Lars Fjellbirkeland; Jody L Baron; John S Munger; Hisaaki Kawakatsu; Dean Sheppard; V Courtney Broaddus; Stephen L Nishimura
Journal:  J Cell Biol       Date:  2002-04-22       Impact factor: 10.539
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