Literature DB >> 26046064

Current progress in genetic research of adolescent idiopathic scoliosis.

Zezhang Zhu1, Leilei Xu1, Yong Qiu1.   

Abstract

Previous genetic linkage analysis and candidate gene association analysis have unveiled dozens of variants associated with the development of adolescent idiopathic scoliosis (AIS), which however can seldom be replicated in different ethnics. Recently, two genome-wide association studies of AIS performed in Japan revealed that ladybird homeobox 1 (LBX1) gene and G protein-coupled receptor 126 (GPR126) gene could play a role in the etiopathogenesis of the disease. Since the association between these two genes and AIS were successfully validated in the Caucasian and the Chinese population, LBX1 gene and GPR126 gene were the most reliable genetic variants underling the development of AIS.

Entities:  

Keywords:  Adolescent idiopathic scoliosis; G protein–coupled receptor 126 (GPR126); genome-wide association study; ladybird homeobox 1 (LBX1)

Year:  2015        PMID： 26046064      PMCID： PMC4437942          DOI： 10.3978/j.issn.2305-5839.2015.02.04

Source DB:  PubMed          Journal:  Ann Transl Med        ISSN： 2305-5839


  29 in total

1.  Identification of candidate regions for familial idiopathic scoliosis.

Authors:  Nancy H Miller; Cristina M Justice; Beth Marosy; Kimberly F Doheny; Elizabeth Pugh; Jun Zhang; Harry C Dietz; Alexander F Wilson
Journal:  Spine (Phila Pa 1976)       Date:  2005-05-15       Impact factor: 3.468

2.  A relook into the association of the estrogen receptor [alpha] gene (PvuII, XbaI) and adolescent idiopathic scoliosis: a study of 540 Chinese cases.

Authors:  Nelson Leung-Sang Tang; Hiu-Yan Yeung; Kwong-Man Lee; Vivian Wing-Yin Hung; Catherine Siu-King Cheung; Bobby Kin-Wah Ng; Rachel Kwok; Xia Guo; Ling Qin; Jack Chun-Yiu Cheng
Journal:  Spine (Phila Pa 1976)       Date:  2006-10-01       Impact factor: 3.468

3.  Genetic analysis of structural elastic fiber and collagen genes in familial adolescent idiopathic scoliosis.

Authors:  N H Miller; B Mims; A Child; D M Milewicz; P Sponseller; S H Blanton
Journal:  J Orthop Res       Date:  1996-11       Impact factor: 3.494

4.  Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population.

Authors:  Yohei Takahashi; Morio Matsumoto; Tatsuki Karasugi; Kota Watanabe; Kazuhiro Chiba; Noriaki Kawakami; Taichi Tsuji; Koki Uno; Teppei Suzuki; Manabu Ito; Hideki Sudo; Shohei Minami; Toshiaki Kotani; Katsuki Kono; Haruhisa Yanagida; Hiroshi Taneichi; Atsushi Takahashi; Yoshiaki Toyama; Shiro Ikegawa
Journal:  J Orthop Res       Date:  2011-02-09       Impact factor: 3.494

5.  Promoter polymorphism of matrilin-1 gene predisposes to adolescent idiopathic scoliosis in a Chinese population.

Authors:  Zhijun Chen; Nelson L S Tang; Xingbin Cao; Di Qiao; Long Yi; Jack C Y Cheng; Yong Qiu
Journal:  Eur J Hum Genet       Date:  2008-11-05       Impact factor: 4.246

6.  Transforming growth factor beta 1 is a novel susceptibility gene for adolescent idiopathic scoliosis.

Authors:  Igor I Ryzhkov; Eugeny E Borzilov; Mikhail I Churnosov; Alexander V Ataman; Andrey A Dedkov; Alexey V Polonikov
Journal:  Spine (Phila Pa 1976)       Date:  2013-05-20       Impact factor: 3.468

7.  Association study of tryptophan hydroxylase 1 and arylalkylamine N-acetyltransferase polymorphisms with adolescent idiopathic scoliosis in Han Chinese.

Authors:  Hai Wang; Zhihong Wu; Qianyu Zhuang; Qi Fei; Jianguo Zhang; Yong Liu; Yipeng Wang; Yaozhong Ding; Guixing Qiu
Journal:  Spine (Phila Pa 1976)       Date:  2008-09-15       Impact factor: 3.468

8.  Association of estrogen receptor beta gene polymorphisms with susceptibility to adolescent idiopathic scoliosis.

Authors:  Hong-Qi Zhang; Shi-Jin Lu; Ming-Xing Tang; Ling-Qiang Chen; Shao-Hua Liu; Chao-Feng Guo; Xi-Yang Wang; Jing Chen; Ling Xie
Journal:  Spine (Phila Pa 1976)       Date:  2009-04-15       Impact factor: 3.468

Review 9.  The role of melatonin in the pathogenesis of adolescent idiopathic scoliosis (AIS).

Authors:  M Girardo; N Bettini; E Dema; S Cervellati
Journal:  Eur Spine J       Date:  2011-03-18       Impact factor: 3.134

10.  Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.

Authors:  Nicole Soranzo; Fernando Rivadeneira; Usha Chinappen-Horsley; Ida Malkina; J Brent Richards; Naomi Hammond; Lisette Stolk; Alexandra Nica; Michael Inouye; Albert Hofman; Jonathan Stephens; Eleanor Wheeler; Pascal Arp; Rhian Gwilliam; P Mila Jhamai; Simon Potter; Amy Chaney; Mohammed J R Ghori; Radhi Ravindrarajah; Sergey Ermakov; Karol Estrada; Huibert A P Pols; Frances M Williams; Wendy L McArdle; Joyce B van Meurs; Ruth J F Loos; Emmanouil T Dermitzakis; Kourosh R Ahmadi; Deborah J Hart; Willem H Ouwehand; Nicholas J Wareham; Inês Barroso; Manjinder S Sandhu; David P Strachan; Gregory Livshits; Timothy D Spector; André G Uitterlinden; Panos Deloukas
Journal:  PLoS Genet       Date:  2009-04-03       Impact factor: 5.917
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  4 in total

1.  Circulating miRNAs as diagnostic biomarkers for adolescent idiopathic scoliosis.

Authors:  José Luis García-Giménez; Pedro Antonio Rubio-Belmar; Lorena Peiró-Chova; David Hervás; Daymé González-Rodríguez; José Santiago Ibañez-Cabellos; Paloma Bas-Hermida; Salvador Mena-Mollá; Eva María García-López; Federico V Pallardó; Teresa Bas
Journal:  Sci Rep       Date:  2018-02-08       Impact factor: 4.379

Review 2.  Global Spine Range of Motion in Patients With Adolescent Idiopathic Scoliosis Before and After Corrective Surgery.

Authors:  Yusuf Mehkri; Jairo Hernandez; Jessica L McQuerry; Johanna Carmona; Stephanie Ihnow
Journal:  Cureus       Date:  2021-11-08

3.  The Effects of Short- and Long-Term Spinal Brace Use with and without Exercise on Spine, Balance, and Gait in Adolescents with Idiopathic Scoliosis.

Authors:  Guilherme Erdmann da Silveira; Rodrigo Mantelatto Andrade; Gean Gustavo Guilhermino; Ariane Verttú Schmidt; Lucas Melo Neves; Ana Paula Ribeiro
Journal:  Medicina (Kaunas)       Date:  2022-07-29       Impact factor: 2.948

Review 4.  Zebrafish Models of Human Skeletal Disorders: Embryo and Adult Swimming Together.

Authors:  Marta Carnovali; Giuseppe Banfi; Massimo Mariotti
Journal:  Biomed Res Int       Date:  2019-11-20       Impact factor: 3.411
  4 in total

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