Literature DB >> 26045997

Elevated expression of HABP1 is correlated with metastasis and poor survival in breast cancer patients.

Ming Niu1, Shanshan Sun1, Guoqiang Zhang1, Yashuang Zhao2, Da Pang1, Yanbo Chen1.   

Abstract

Hyaluronan-binding protein 1 (HABP1) is a protein with high affinity for HA, and has been reported to be upregulated in cancer cells. In this study, we show that silencing HABP1 inhibits proliferation, and suppresses the migration and invasion ability of breast cancer cell lines. In addition, silencing HABP1 remarkably slows down tumor growth in mice. We examined the correlation between HABP1 expression and clinicopathological parameters using immunohistochemistry in patients with breast cancer. The results indicate that HABP1 is overexpressed in cancer tissue, and its high levels are related to lymph node metastasis (P = 0.032) and tumor stage (P = 0.041). Moreover, high HABP1 expression is correlated with poor overall survival in breast cancer patients (P = 0.018), and is a signifi cant independent prognostic indicator. Our fi ndings suggest that HABP1 regulates proliferation and migration of breast cancer cells. HABP1 may be a useful independent predictor of outcomes in patients with breast cancer.

Entities:  

Keywords:  HABP1; breast cancer; metastasis

Year:  2015        PMID： 26045997      PMCID： PMC4449446     

Source DB:  PubMed          Journal:  Am J Cancer Res        ISSN： 2156-6976            Impact factor:   6.166


  27 in total

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Journal:  J Biol Chem       Date:  1996-01-26       Impact factor: 5.157

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8.  Complement 1q-binding protein inhibits the mitochondrial permeability transition pore and protects against oxidative stress-induced death.

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Journal:  Biochem J       Date:  2011-01-01       Impact factor: 3.857

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Journal:  Mol Cell Biol       Date:  2010-01-25       Impact factor: 4.272
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  10 in total

1.  The proteome signature of the inflammatory breast cancer plasma membrane identifies novel molecular markers of disease.

Authors:  Ivette J Suárez-Arroyo; Yismeilin R Feliz-Mosquea; Juliana Pérez-Laspiur; Rezina Arju; Shah Giashuddin; Gerónimo Maldonado-Martínez; Luis A Cubano; Robert J Schneider; Michelle M Martínez-Montemayor
Journal:  Am J Cancer Res       Date:  2016-08-01       Impact factor: 6.166

2.  gC1qR/C1qBP/HABP-1: Structural Analysis of the Trimeric Core Region, Interactions With a Novel Panel of Monoclonal Antibodies, and Their Influence on Binding to FXII.

Authors:  Ying Zhang; Alexander J Vontz; Ethan M Kallenberger; Xin Xu; Nicoleta T Ploscariu; Kasra X Ramyar; Brandon L Garcia; Berhane Ghebrehiwet; Brian V Geisbrecht
Journal:  Front Immunol       Date:  2022-07-05       Impact factor: 8.786

Review 3.  An approach to p32/gC1qR/HABP1: a multifunctional protein with an essential role in cancer.

Authors:  Carlos Alejandro Egusquiza-Alvarez; Martha Robles-Flores
Journal:  J Cancer Res Clin Oncol       Date:  2022-04-20       Impact factor: 4.322

4.  Prognostic and functional role of hyaluronan-binding protein 1 in pancreatic ductal adenocarcinoma.

Authors:  Yasuhiro Adachi; Norihiro Sato; Takuya Oba; Takao Amaike; Yuzan Kudo; Shiro Kohi; Toshiyuki Nakayama; Keiji Hirata
Journal:  Oncol Lett       Date:  2022-05-23       Impact factor: 3.111

5.  Hyaluronic acid binding protein 1 overexpression is an indicator for disease-free survival in cervical cancer.

Authors:  Ming Zhang; Na Li; Yannan Liang; Jinhui Liu; Yafeng Zhou; Chunying Liu
Journal:  Int J Clin Oncol       Date:  2016-12-30       Impact factor: 3.402

6.  Elevated HABP1 protein expression correlates with progression and poor survival in patients with gastric cancer.

Authors:  Hongyu Gao; Qiang Yao; Xiuwen Lan; Sen Li; Junlong Wu; Guangchun Zeng; Yingwei Xue
Journal:  Onco Targets Ther       Date:  2016-10-31       Impact factor: 4.147

7.  Increased breast cancer risk with HABP1/p32/gC1qR genetic polymorphism rs2285747 and its upregulation in northern Chinese women.

Authors:  Yongdong Jiang; Hao Wu; Jing Liu; Yanbo Chen; Jingjing Xie; Yashuang Zhao; Da Pang
Journal:  Oncotarget       Date:  2017-02-21

Review 8.  Multi-functional, multicompartmental hyaluronan-binding protein 1 (HABP1/p32/gC1qR): implication in cancer progression and metastasis.

Authors:  Paramita Saha; Kasturi Datta
Journal:  Oncotarget       Date:  2018-01-09

9.  Hypoxia-Mediated Complement 1q Binding Protein Regulates Metastasis and Chemoresistance in Triple-Negative Breast Cancer and Modulates the PKC-NF-κB-VCAM-1 Signaling Pathway.

Authors:  Hao Wu; Yijun Chu; Shanshan Sun; Guozheng Li; Shouping Xu; Xianyu Zhang; Yongdong Jiang; Song Gao; Qin Wang; Jian Zhang; Da Pang
Journal:  Front Cell Dev Biol       Date:  2021-02-23

10.  Globular C1q Receptor (gC1qR/p32/HABP1) Suppresses the Tumor-Inhibiting Role of C1q and Promotes Tumor Proliferation in 1q21-Amplified Multiple Myeloma.

Authors:  Jiadai Xu; Yifeng Sun; Jifeng Jiang; Zhao Xu; Jing Li; Tianhong Xu; Peng Liu
Journal:  Front Immunol       Date:  2020-07-14       Impact factor: 7.561
  10 in total

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