| Literature DB >> 26045864 |
Yosuke Tanaka1, Yukio Kobayashi1, Akiko Miyagi Maeshima2, Sung Yong Oh3, Junko Nomoto1, Suguru Fukuhara1, Hideaki Kitahara1, Wataru Munakata1, Tatsuya Suzuki1, Dai Maruyama1, Kensei Tobinai1.
Abstract
Intravascular large B-cell lymphoma (IVLBCL) can be a fatal malignancy mainly because of difficulty in early detection. Due to the lack of specific clinical manifestations, early detection of IVLBCL remains a challenge, especially in the presence of comorbidities. Lymphoplasmacytic lymphoma (LPL) is an indolent B-cell lymphoma accompanied by monoclonal immunoglobulin M protein in most patients, and known to be associated with high risk of secondary hematological malignancies. Here, we report a patient who developed IVLBCL during treatment for LPL that presented a diagnostic challenge. Rearrangement analysis of the immunoglobulin heavy chain revealed the different clonal origins of two lymphomas, implying a predisposition of LPL to develop unrelated secondary lymphoma. Secondary lymphoma including IVLBCL during the treatment for LPL deserves consideration in order to facilitate early diagnosis and intervention.Entities:
Keywords: Intravascular large B-cell lymphoma; immunoglobulin rearrangement; lymphoplasmacytic lymphoma; secondary lymphoma
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Year: 2015 PMID： 26045864 PMCID： PMC4440173
Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625