Yingtian Wang1, Xingguang Wang2, Xiyan Wang3, Deyong Zhang1, Shujuan Jiang2. 1. Department of Respiratory Medicine, Dongying People's Hospital of Shandong Province Dongying 257091, Shandong, China. 2. Department of Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, Shandong, China. 3. Department of Respiratory Medicine, Qianfo Mountain Hospital of Shandong University Jinan 250014, Shandong, China.
Abstract
BACKGROUND: The Transforming growth factor-β1 (TGFβ1) 869C/T polymorphism was associated with radiation pneumonitis (RP) susceptibility. However, the results remained controversial. Thus, a meta-analysis was conducted. METHODS: Relevant studies were systematically searched by using the NCBI, Medline, Web of Science and Embase databases. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models. RESULTS: There was a significant association between TGFβ1 869C/T polymorphism and RP susceptibility (OR=1.77; 95% CI, 1.27-2.47; P=0.0007). CONCLUSION: This study suggested that TGFβ1 869C/T polymorphism was a risk factor of RP.
BACKGROUND: The Transforming growth factor-β1 (TGFβ1) 869C/T polymorphism was associated with radiation pneumonitis (RP) susceptibility. However, the results remained controversial. Thus, a meta-analysis was conducted. METHODS: Relevant studies were systematically searched by using the NCBI, Medline, Web of Science and Embase databases. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models. RESULTS: There was a significant association between TGFβ1 869C/T polymorphism and RP susceptibility (OR=1.77; 95% CI, 1.27-2.47; P=0.0007). CONCLUSION: This study suggested that TGFβ1 869C/T polymorphism was a risk factor of RP.
Authors: An M Voets; Cary Oberije; Robin B Struijk; Bart Reymen; Kim De Ruyck; Hubert Thierens; Katrien Vandecasteele; Wilfried De Neve; Ruud Houben; Dirk De Ruysscher; Hubert J M Smeets; Philippe Lambin Journal: Radiother Oncol Date: 2012-11-03 Impact factor: 6.280
Authors: M S Anscher; F M Kong; K Andrews; R Clough; L B Marks; G Bentel; R L Jirtle Journal: Int J Radiat Oncol Biol Phys Date: 1998-07-15 Impact factor: 7.038
Authors: D J Grainger; K Heathcote; M Chiano; H Snieder; P R Kemp; J C Metcalfe; N D Carter; T D Spector Journal: Hum Mol Genet Date: 1999-01 Impact factor: 6.150