Literature DB >> 2604538

[Synthesis of racemates and enantiomers of 3-alkylthalidomide analogs and determination of their absolute configuration].

J Knabe, G Omlor.   

Abstract

The syntheses of the racemates and the enantiomers of the title compounds 7a-7c and of racem. 1,3-dimethyl-thalidomide (8) are reported. The absolute configuration of the optically active products is determined. The hypnotic activities of the analogs of thalidomide 7a - 7c and of the intermediates 6a - 6c are to be tested in animals.

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Year:  1989        PMID: 2604538     DOI: 10.1002/ardp.19893220809

Source DB:  PubMed          Journal:  Arch Pharm (Weinheim)        ISSN: 0365-6233            Impact factor:   3.751


  3 in total

1.  Sequential Ruthenium Catalysis for Olefin Isomerization and Oxidation: Application to the Synthesis of Unusual Amino Acids.

Authors:  Marc Liniger; Yiyang Liu; Brian M Stoltz
Journal:  J Am Chem Soc       Date:  2017-09-25       Impact factor: 15.419

2.  Differentiation of antiinflammatory and antitumorigenic properties of stabilized enantiomers of thalidomide analogs.

Authors:  Vincent Jacques; Anthony W Czarnik; Thomas M Judge; Lex H T Van der Ploeg; Sheila H DeWitt
Journal:  Proc Natl Acad Sci U S A       Date:  2015-03-09       Impact factor: 11.205

3.  Enantioselective gas chromatographic separation of racemic N-alkylated barbiturates: application of C11-Chirasil-Dex as chiral stationary phase in GC.

Authors:  Ashraf Ghanem
Journal:  Anal Chem Insights       Date:  2007-09-18
  3 in total

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