Dylan R Kirn1, Afsaneh Koochek2, Kieran F Reid3, Åsa von Berens2, Thomas G Travison4, Sara Folta5, Jennifer Sacheck5, Miriam Nelson6, Christine Liu7, Edward Phillips8, Anna Cristina Åberg9, Margaretha Nydahl10, Thomas Gustafsson11, Tommy Cederholm2, Roger A Fielding3. 1. Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States. Electronic address: Dylan.kirn@tufts.edu. 2. Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. 3. Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States. 4. Institute for Aging Research, Hebrew SeniorLife, Boston, MA, United States; Harvard Medical School, Boston, MA, United States; Division of Gerontology, Beth Israel Deaconess Medical Center, Boston, MA, United States. 5. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States. 6. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States; Jonathan M. Tisch College of Citizenship and Public Service, Tufts University, Medford, MA, United States. 7. Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States; Section of Geriatrics, Boston University School of Medicine, Boston, MA, United States. 8. Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States; Harvard Medical School, Boston, MA, United States; Spaulding Rehabilitation Hospital, Boston, MA, United States. 9. Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden; School of Education, Health and Society, Dalarna University, Sweden. 10. Department of Food, Nutrition and Dietetics, Uppsala University, Uppsala, Sweden. 11. Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Abstract
BACKGROUND:Nutritional supplementation may potentiate the increase in skeletal muscle protein synthesis following exercise in healthy older individuals. Whether exercise and nutrition act synergistically to produce sustained changes in physical functioning and body composition has not been well studied, particularly in mobility-limited older adults. METHODS: The VIVE2 study was a multi-center, randomized controlled trial, conducted in the United States and Sweden. This study was designed to compare the effects of a 6-month intervention with a once daily, experimental, 4 fl.oz. liquid nutritional supplement providing 150 kcal, whey protein (20 g), and vitamin D (800 IU) (Nestlé Health Science, Vevey, Switzerland), to a low calorie placebo drink (30 kcal, non-nutritive; identical format) when combined with group-based exercise in 150 community-dwelling, mobility-limited older adults. All participants participated in a structured exercise program (3 sessions/week for 6 months), which included aerobic, strength, flexibility, and balance exercises. RESULTS: The primary outcome was 6-month change in 400 m walk performance (m/s) between supplement and placebo groups. Secondary outcomes included 6 month change in: body composition, muscle cross-sectional area, leg strength, grip strength, stair climb time, quality of life, physical performance, mood/depressive symptoms and nutritional status. These outcomes were selected based on their applicability to the health and well-being of older adults. CONCLUSIONS: The results of this study will further define the role of nutritional supplementation on physical functioning and restoration of skeletal muscle mass in older adults. Additionally, these results will help refine the current physical activity and nutritional recommendations for mobility-limited older adults.
RCT Entities:
BACKGROUND: Nutritional supplementation may potentiate the increase in skeletal muscle protein synthesis following exercise in healthy older individuals. Whether exercise and nutrition act synergistically to produce sustained changes in physical functioning and body composition has not been well studied, particularly in mobility-limited older adults. METHODS: The VIVE2 study was a multi-center, randomized controlled trial, conducted in the United States and Sweden. This study was designed to compare the effects of a 6-month intervention with a once daily, experimental, 4 fl.oz. liquid nutritional supplement providing 150 kcal, whey protein (20 g), and vitamin D (800 IU) (Nestlé Health Science, Vevey, Switzerland), to a low calorie placebo drink (30 kcal, non-nutritive; identical format) when combined with group-based exercise in 150 community-dwelling, mobility-limited older adults. All participants participated in a structured exercise program (3 sessions/week for 6 months), which included aerobic, strength, flexibility, and balance exercises. RESULTS: The primary outcome was 6-month change in 400 m walk performance (m/s) between supplement and placebo groups. Secondary outcomes included 6 month change in: body composition, muscle cross-sectional area, leg strength, grip strength, stair climb time, quality of life, physical performance, mood/depressive symptoms and nutritional status. These outcomes were selected based on their applicability to the health and well-being of older adults. CONCLUSIONS: The results of this study will further define the role of nutritional supplementation on physical functioning and restoration of skeletal muscle mass in older adults. Additionally, these results will help refine the current physical activity and nutritional recommendations for mobility-limited older adults.
Authors: R A Fielding; T G Travison; D R Kirn; A Koochek; K F Reid; Å von Berens; H Zhu; S C Folta; J M Sacheck; M E Nelson; C K Liu; A C Åberg; M Nydahl; M Lilja; T Gustafsson; T Cederholm Journal: J Nutr Health Aging Date: 2017 Impact factor: 4.075
Authors: Å von Berens; T Cederholm; R A Fielding; T Gustafsson; D Kirn; J Laussen; M Nydahl; T G Travison; K Reid; A Koochek Journal: J Nutr Health Aging Date: 2018 Impact factor: 4.075
Authors: Peggy M Cawthon; Thomas G Travison; Todd M Manini; Sheena Patel; Karol M Pencina; Roger A Fielding; Jay M Magaziner; Anne B Newman; Todd Brown; Douglas P Kiel; Steve R Cummings; Michelle Shardell; Jack M Guralnik; Linda J Woodhouse; Marco Pahor; Ellen Binder; Ralph B D'Agostino; Xue Quian-Li; Eric Orwoll; Francesco Landi; Denise Orwig; Laura Schaap; Nancy K Latham; Vasant Hirani; Timothy Kwok; Suzette L Pereira; Daniel Rooks; Makoto Kashiwa; Moises Torres-Gonzalez; Joseph P Menetski; Rosaly Correa-De-Araujo; Shalender Bhasin Journal: J Gerontol A Biol Sci Med Sci Date: 2020-06-18 Impact factor: 6.053
Authors: Roger A Fielding; Andrew R Reeves; Ravi Jasuja; Christine Liu; Brittany B Barrett; Michael S Lustgarten Journal: Exp Gerontol Date: 2019-09-04 Impact factor: 4.032
Authors: Å von Berens; A Koochek; M Nydahl; R A Fielding; T Gustafsson; D R Kirn; T Cederholm; M Södergren Journal: J Nutr Health Aging Date: 2018 Impact factor: 4.075
Authors: Gregory J Grosicki; Thomas G Travison; Hao Zhu; Jay Magaziner; Ellen F Binder; Marco Pahor; Rosaly Correa-de-Araujo; Peggy M Cawthon; Shalender Bhasin; Denise Orwig; Susan Greenspan; Todd Manini; Joe Massaro; Adam Santanasto; Sheena Patel; Roger A Fielding Journal: J Am Geriatr Soc Date: 2020-07-07 Impact factor: 5.562
Authors: Åsa von Berens; Roger A Fielding; Thomas Gustafsson; Dylan Kirn; Jonathan Laussen; Margaretha Nydahl; Kieran Reid; Thomas G Travison; Hao Zhu; Tommy Cederholm; Afsaneh Koochek Journal: BMC Geriatr Date: 2018-11-21 Impact factor: 3.921
Authors: Davis A Englund; Dylan R Kirn; Afsaneh Koochek; Hao Zhu; Thomas G Travison; Kieran F Reid; Åsa von Berens; Michael Melin; Tommy Cederholm; Thomas Gustafsson; Roger A Fielding Journal: J Gerontol A Biol Sci Med Sci Date: 2017-12-12 Impact factor: 6.053
Authors: Julian Vallejo; Madoka Spence; An-Lin Cheng; Leticia Brotto; Neile K Edens; Sean M Garvey; Marco Brotto Journal: PLoS One Date: 2016-03-08 Impact factor: 3.240