Literature DB >> 26044188

Accuracy of micro powder dosing via a vibratory sieve-chute system.

M O Besenhard1, E Faulhammer1, S Fathollahi2, G Reif3, V Calzolari4, S Biserni4, A Ferrari4, S M Lawrence5, M Llusa2, J G Khinast6.   

Abstract

This paper describes a powder dosing system with a vibratory sieve mounted on a chute that doses particles into a capsule. Vertical vibration occurred with a broad range of frequencies and amplitudes. During dosing events, the fill weight was accurately recorded via a capacitance sensor, covering the capsules and making it possible to analyze filling characteristics, that is, the fill rates and their robustness. The range of frequencies and amplitudes was screened for settings that facilitated reasonable (no blocking, no spilling) fill rates for three lactose powders. The filling characteristics were studied within this operating space. The results reveal similar operating spaces for all investigated powders. The fill rate robustness varied distinctly in the operating space, which is of prime importance for selecting the settings for continuous feeding applications. In addition, we present accurate dosing studies utilizing the knowledge about the filling characteristics of each powder.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Capsule filling; Lactose; Micro dosing; Micro feeding; Online scale; Vibratory sieve

Mesh:

Substances:

Year:  2015        PMID: 26044188     DOI: 10.1016/j.ejpb.2015.04.037

Source DB:  PubMed          Journal:  Eur J Pharm Biopharm        ISSN: 0939-6411            Impact factor:   5.571


  1 in total

1.  Micro-Dosing of Fine Cohesive Powders Actuated by Pulse Inertia Force.

Authors:  Hongcheng Wang; Ting Zhang; Miaomiao Zhao; Rangrang Chen; Liqun Wu
Journal:  Micromachines (Basel)       Date:  2018-02-07       Impact factor: 2.891

  1 in total

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