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Literature DB >> 26043873

Hepatocyte-specific Hmgb1 Deletion.

Abstract

High mobility group box 1 (HMGB1) plays a key role in human health and disease. Currently, three different labs in the USA use Cre-lox technology to create mice with a hepatocyte-specific Hmgb1 deletion (HMGB1-HC-KO mice) by backcrossing Hmgb1 (flox)/(flox) mice to Alb-Cre mice. This mouse strain has a different phenotype following exposure to several stressors.

Entities: Gene Species

Keywords: HMGB1, knockout, liver, mice

Mesh：

Substances：
HMGB1 Protein

Year: 2015 PMID： 26043873 PMCID： PMC4590590 DOI： 10.1080/15548627.2015.1054595

Source DB: PubMed Journal: Autophagy ISSN： 1554-8627 Impact factor: 16.016

21 in total

1. Activation of autophagy protects against acetaminophen-induced hepatotoxicity.

Authors: Hong-Min Ni; Abigail Bockus; Nikki Boggess; Hartmut Jaeschke; Wen-Xing Ding
Journal: Hepatology Date: 2011-12-06 Impact factor: 17.425

2. Loss of autophagy in the central nervous system causes neurodegeneration in mice.

Authors: Masaaki Komatsu; Satoshi Waguri; Tomoki Chiba; Shigeo Murata; Jun-ichi Iwata; Isei Tanida; Takashi Ueno; Masato Koike; Yasuo Uchiyama; Eiki Kominami; Keiji Tanaka
Journal: Nature Date: 2006-04-19 Impact factor: 49.962

3. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice.

Authors: Taichi Hara; Kenji Nakamura; Makoto Matsui; Akitsugu Yamamoto; Yohko Nakahara; Rika Suzuki-Migishima; Minesuke Yokoyama; Kenji Mishima; Ichiro Saito; Hideyuki Okano; Noboru Mizushima
Journal: Nature Date: 2006-04-19 Impact factor: 49.962

4. The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis.

Authors: Peter Huebener; Jean-Philippe Pradere; Celine Hernandez; Geum-Youn Gwak; Jorge Matias Caviglia; Xueru Mu; John D Loike; Robert F Schwabe
Journal: J Clin Invest Date: 2014-12-22 Impact factor: 14.808

5. Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice.

Authors: Wen-Xing Ding; Min Li; Xiaoyun Chen; Hong-Min Ni; Chih-Wen Lin; Wentao Gao; Binfeng Lu; Donna B Stolz; Dahn L Clemens; Xiao-Ming Yin
Journal: Gastroenterology Date: 2010-07-23 Impact factor: 22.682

6. Ethanol administration alters the proteolytic activity of hepatic lysosomes.

Authors: T M Donohue; D L McVicker; K K Kharbanda; M L Chaisson; R K Zetterman
Journal: Alcohol Clin Exp Res Date: 1994-06 Impact factor: 3.455

7. Methods for monitoring autophagy using GFP-LC3 transgenic mice.

Authors: Noboru Mizushima
Journal: Methods Enzymol Date: 2009 Impact factor: 1.600

Review 8. Emerging role of high-mobility group box 1 (HMGB1) in liver diseases.

Authors: Ruochan Chen; Wen Hou; Qiuhong Zhang; Rui Kang; Xue-Gong Fan; Daolin Tang
Journal: Mol Med Date: 2013-11-08 Impact factor: 6.354

9. Endogenous HMGB1 regulates autophagy.

Authors: Daolin Tang; Rui Kang; Kristen M Livesey; Chun-Wei Cheh; Adam Farkas; Patricia Loughran; George Hoppe; Marco E Bianchi; Kevin J Tracey; Herbert J Zeh; Michael T Lotze
Journal: J Cell Biol Date: 2010-09-06 Impact factor: 10.539

10. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice.

Authors: Masaaki Komatsu; Satoshi Waguri; Takashi Ueno; Junichi Iwata; Shigeo Murata; Isei Tanida; Junji Ezaki; Noboru Mizushima; Yoshinori Ohsumi; Yasuo Uchiyama; Eiki Kominami; Keiji Tanaka; Tomoki Chiba
Journal: J Cell Biol Date: 2005-05-02 Impact factor: 10.539

1 in total

1. Novel dihydroartemisinin derivative DHA-37 induces autophagic cell death through upregulation of HMGB1 in A549 cells.

Authors: Xiufeng Liu; Juanjuan Wu; Menglin Fan; Chen Shen; Wenling Dai; Yini Bao; Ji-Hua Liu; Bo-Yang Yu
Journal: Cell Death Dis Date: 2018-10-15 Impact factor: 8.469

1 in total