Literature DB >> 26043755

Intracellular calcium signaling regulates autophagy via calcineurin-mediated TFEB dephosphorylation.

Yanju Tong1, Fuyong Song.   

Abstract

The transcription-regulating activity of TFEB is dependent on its phosphorylation modification, but the phosphatase(s) involved in TFEB dephosphorylation have remained elusive. It has now become clear that lysosomal calcium signaling activates calcineurin, an endogenous serine/threonine phosphatase, which dephosphorylate TFEB leading to upregulation of autophagy.

Entities:  

Keywords:  calcineurin; calcium signaling; transcription factor EB

Mesh：

Substances：

Year:  2015        PMID： 26043755      PMCID： PMC4590610          DOI： 10.1080/15548627.2015.1054594

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   16.016


  27 in total

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Authors:  Noboru Mizushima; Daniel J Klionsky
Journal:  Annu Rev Nutr       Date:  2007       Impact factor: 11.848

2.  TFEB and the CLEAR network.

Authors:  Carmine Settembre; Diego L Medina
Journal:  Methods Cell Biol       Date:  2015-01-19       Impact factor: 1.441

3.  A RANKL-PKCβ-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts.

Authors:  Mathieu Ferron; Carmine Settembre; Junko Shimazu; Julie Lacombe; Shigeaki Kato; David J Rawlings; Andrea Ballabio; Gerard Karsenty
Journal:  Genes Dev       Date:  2013-04-18       Impact factor: 11.361

4.  The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.

Authors:  Agnes Roczniak-Ferguson; Constance S Petit; Florian Froehlich; Sharon Qian; Jennifer Ky; Brittany Angarola; Tobias C Walther; Shawn M Ferguson
Journal:  Sci Signal       Date:  2012-06-12       Impact factor: 8.192

5.  Calpain, Atg5 and Bak play important roles in the crosstalk between apoptosis and autophagy induced by influx of extracellular calcium.

Authors:  Mei Shi; Tian Zhang; Lei Sun; Yan Luo; De-Hua Liu; Shu-Tao Xie; Xiao-Yan Song; Guo-Fan Wang; Xiu-Lan Chen; Bai-Cheng Zhou; Yu-Zhong Zhang
Journal:  Apoptosis       Date:  2013-04       Impact factor: 4.677

Review 6.  Regulation mechanisms and signaling pathways of autophagy.

Authors:  Congcong He; Daniel J Klionsky
Journal:  Annu Rev Genet       Date:  2009       Impact factor: 16.830

7.  Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.

Authors:  Maria Høyer-Hansen; Lone Bastholm; Piotr Szyniarowski; Michelangelo Campanella; György Szabadkai; Thomas Farkas; Katiuscia Bianchi; Nicole Fehrenbacher; Folmer Elling; Rosario Rizzuto; Ida Stenfeldt Mathiasen; Marja Jäättelä
Journal:  Mol Cell       Date:  2007-01-26       Impact factor: 17.970

8.  A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.

Authors:  Carmine Settembre; Roberto Zoncu; Diego L Medina; Francesco Vetrini; Serkan Erdin; SerpilUckac Erdin; Tuong Huynh; Mathieu Ferron; Gerard Karsenty; Michel C Vellard; Valeria Facchinetti; David M Sabatini; Andrea Ballabio
Journal:  EMBO J       Date:  2012-02-17       Impact factor: 11.598

Review 9.  Signals from the lysosome: a control centre for cellular clearance and energy metabolism.

Authors:  Carmine Settembre; Alessandro Fraldi; Diego L Medina; Andrea Ballabio
Journal:  Nat Rev Mol Cell Biol       Date:  2013-05       Impact factor: 94.444

10.  Lysosomal calcium signalling regulates autophagy through calcineurin and ​TFEB.

Authors:  Diego L Medina; Simone Di Paola; Ivana Peluso; Andrea Armani; Diego De Stefani; Rossella Venditti; Sandro Montefusco; Anna Scotto-Rosato; Carolina Prezioso; Alison Forrester; Carmine Settembre; Wuyang Wang; Qiong Gao; Haoxing Xu; Marco Sandri; Rosario Rizzuto; Maria Antonietta De Matteis; Andrea Ballabio
Journal:  Nat Cell Biol       Date:  2015-03       Impact factor: 28.824
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  25 in total

1.  Calcineurin Regulatory Subunit Calcium-Binding Domains Differentially Contribute to Calcineurin Signaling in Saccharomyces cerevisiae.

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Journal:  Genetics       Date:  2018-05-07       Impact factor: 4.562

2.  m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.

Authors:  Yabing Chen; Jing Wang; Dihui Xu; Zou Xiang; Jie Ding; Xiaoyu Yang; Dongmei Li; Xiaodong Han
Journal:  Autophagy       Date:  2020-01-31       Impact factor: 16.016

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Journal:  Am J Respir Crit Care Med       Date:  2019-08-01       Impact factor: 21.405

Review 4.  Molecular Mechanisms of Lysosome and Nucleus Communication.

Authors:  Qian Zhao; Shihong Max Gao; Meng C Wang
Journal:  Trends Biochem Sci       Date:  2020-07-02       Impact factor: 13.807

5.  A negative feedback regulation of MTORC1 activity by the lysosomal Ca2+ channel MCOLN1 (mucolipin 1) using a CALM (calmodulin)-dependent mechanism.

Authors:  Xue Sun; Yiming Yang; Xi Zoë Zhong; Qi Cao; Xin-Hong Zhu; Xiaojuan Zhu; Xian-Ping Dong
Journal:  Autophagy       Date:  2018-02-20       Impact factor: 16.016

6.  YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization.

Authors:  Yang Xu; Jinqi Ren; Xiaolong He; Han Chen; Taotao Wei; Wei Feng
Journal:  Autophagy       Date:  2019-01-27       Impact factor: 16.016

Review 7.  Neuronal autophagy and axon degeneration.

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Journal:  Cell Mol Life Sci       Date:  2018-04-19       Impact factor: 9.261

Review 8.  A central role for calcineurin in protein misfolding neurodegenerative diseases.

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9.  Dantrolene Ameliorates Impaired Neurogenesis and Synaptogenesis in Induced Pluripotent Stem Cell Lines Derived from Patients with Alzheimer's Disease.

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Review 10.  Niemann-Pick type C disease: The atypical sphingolipidosis.

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Journal:  Adv Biol Regul       Date:  2018-08-28
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