Literature DB >> 26043382

Complement: an overview for the clinician.

Juan Carlos Varela1, Stephen Tomlinson2.   

Abstract

The complement system is an essential component of the immune system. It is a highly integrative system and has a number of functions, including host defense, removal of injured cells and debris, modulation of metabolic and regenerative processes, and regulation of adaptive immunity. Complement is activated via different pathways and it is regulated tightly by several mechanisms to prevent host injury. Imbalance between complement activation and regulation can manifest in disease and injury to self. This article provides an outline of complement activation pathways, regulatory mechanisms, and normal physiologic functions of the system. Published by Elsevier Inc.

Entities:  

Keywords:  Complement activation; Complement function; Complement regulation; Complement system; Immune response; Inflammation

Mesh：

Substances：

Year:  2015        PMID： 26043382      PMCID： PMC4456616          DOI： 10.1016/j.hoc.2015.02.001

Source DB:  PubMed          Journal:  Hematol Oncol Clin North Am        ISSN： 0889-8588            Impact factor:   3.722


  98 in total

Review 1.  Complement and the central nervous system: emerging roles in development, protection and regeneration.

Authors:  Martin J Rutkowski; Michael E Sughrue; Ari J Kane; Steven A Mills; Shanna Fang; Andrew T Parsa
Journal:  Immunol Cell Biol       Date:  2010-04-20       Impact factor: 5.126

Review 2.  The role of the complement system in innate immunity.

Authors:  Horea Rus; Cornelia Cudrici; Florin Niculescu
Journal:  Immunol Res       Date:  2005       Impact factor: 2.829

Review 3.  The role of complement and its receptor in the elimination of immune complexes.

Authors:  J A Schifferli; Y C Ng; D K Peters
Journal:  N Engl J Med       Date:  1986-08-21       Impact factor: 91.245

4.  Chemotactic response to human C3a and C5a anaphylatoxins. I. Evaluation of C3a and C5a leukotaxis in vitro and under stimulated in vivo conditions.

Authors:  H N Fernandez; P M Henson; A Otani; T E Hugli
Journal:  J Immunol       Date:  1978-01       Impact factor: 5.422

5.  A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation.

Authors:  A Coxon; P Rieu; F J Barkalow; S Askari; A H Sharpe; U H von Andrian; M A Arnaout; T N Mayadas
Journal:  Immunity       Date:  1996-12       Impact factor: 31.745

Review 6.  C-reactive protein reactivity with complement and effects on phagocytosis.

Authors:  C Mold; T W Du Clos; S Nakayama; K M Edwards; H Gewurz
Journal:  Ann N Y Acad Sci       Date:  1982       Impact factor: 5.691

Review 7.  C-reactive protein and the acute phase response.

Authors:  H Gewurz; C Mold; J Siegel; B Fiedel
Journal:  Adv Intern Med       Date:  1982

Review 8.  STEC-HUS, atypical HUS and TTP are all diseases of complement activation.

Authors:  Marina Noris; Federica Mescia; Giuseppe Remuzzi
Journal:  Nat Rev Nephrol       Date:  2012-09-18       Impact factor: 28.314

9.  Complement component 3 is required for optimal expansion of CD8 T cells during a systemic viral infection.

Authors:  M Suresh; Hector Molina; Maria S Salvato; Dimitrios Mastellos; John D Lambris; Matyas Sandor
Journal:  J Immunol       Date:  2003-01-15       Impact factor: 5.422

10.  Functional properties of membrane-associated complement receptor CR1.

Authors:  K Iida; V Nussenzweig
Journal:  J Immunol       Date:  1983-04       Impact factor: 5.422
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  15 in total

Review 1.  Cold agglutinin disease.

Authors:  Sigbjørn Berentsen
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2016-12-02

Review 2.  Obesity "complements" preeclampsia.

Authors:  Kelsey N Olson; Leanne M Redman; Jenny L Sones
Journal:  Physiol Genomics       Date:  2019-02-04       Impact factor: 3.107

Review 3.  Complementopathies and precision medicine.

Authors:  Eleni Gavriilaki; Robert A Brodsky
Journal:  J Clin Invest       Date:  2020-05-01       Impact factor: 14.808

4.  Otopathogenic Pseudomonas aeruginosa Enters and Survives Inside Macrophages.

Authors:  Rahul Mittal; Christopher V Lisi; Hansi Kumari; M'hamed Grati; Patricia Blackwelder; Denise Yan; Chaitanya Jain; Kalai Mathee; Paulo H Weckwerth; Xue Z Liu
Journal:  Front Microbiol       Date:  2016-11-18       Impact factor: 5.640

Review 5.  Porphyromonas gingivalis disturbs host-commensal homeostasis by changing complement function.

Authors:  Ingar Olsen; John D Lambris; George Hajishengallis
Journal:  J Oral Microbiol       Date:  2017-06-30       Impact factor: 5.474

6.  Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.

Authors:  Xuan Yuan; Eleni Gavriilaki; Jane A Thanassi; Guangwei Yang; Andrea C Baines; Steven D Podos; Yongqing Huang; Mingjun Huang; Robert A Brodsky
Journal:  Haematologica       Date:  2016-11-03       Impact factor: 9.941

7.  LncRNAs KB-1836B5, LINC00566 and FAM27L are associated with the survival time of patients with ovarian cancer.

Authors:  Huijian Li; Mi Gong; Min Zhao; Xinru Wang; Wenjun Cheng; Yankai Xia
Journal:  Oncol Lett       Date:  2018-07-12       Impact factor: 2.967

8.  Understanding the Role of Anti-PEG Antibodies in the Complement Activation by Doxil in Vitro.

Authors:  Barry W Neun; Yechezkel Barenholz; Janos Szebeni; Marina A Dobrovolskaia
Journal:  Molecules       Date:  2018-07-12       Impact factor: 4.411

9.  European Society for Immunodeficiencies (ESID) and European Reference Network on Rare Primary Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN RITA) Complement Guideline: Deficiencies, Diagnosis, and Management.

Authors:  Nicholas Brodszki; Ashley Frazer-Abel; Anete S Grumach; Michael Kirschfink; Jiri Litzman; Elena Perez; Mikko R J Seppänen; Kathleen E Sullivan; Stephen Jolles
Journal:  J Clin Immunol       Date:  2020-02-17       Impact factor: 8.317

10.  Complement levels in patients with bloodstream infection due to Staphylococcus aureus or Gram-negative bacteria.

Authors:  Emily M Eichenberger; Michael Dagher; Felicia Ruffin; Lawrence Park; Lisa Hersh; Sumathi Sivapalasingam; Vance G Fowler; Brinda C Prasad
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2020-07-04       Impact factor: 5.103
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