| Literature DB >> 26042718 |
Sujata Patra1, Sudip Mukherjee1, Ayan Kumar Barui1, Anirban Ganguly1, Bojja Sreedhar2, Chitta Ranjan Patra3.
Abstract
In the present article, we demonstrate the delivery of anti-cancer drug to the cancer cells using biosynthesized gold and silver nanoparticles (b-AuNP & b-AgNP). The nanoparticles synthesized by using Butea monosperma (BM) leaf extract are thoroughly characterized by various analytical techniques. Both b-AuNP and b-AgNP are stable in biological buffers and biocompatible towards normal endothelial cells (HUVEC, ECV-304) as well as cancer cell lines (B16F10, MCF-7, HNGC2 & A549). Administration of nanoparticle based drug delivery systems (DDSs) using doxorubicin (DOX) [b-Au-500-DOX and b-Ag-750-DOX] shows significant inhibition of cancer cell proliferation (B16F10, MCF-7) compared to pristine drug. Therefore, we strongly believe that biosynthesized nanoparticles will be useful for the development of cancer therapy using nanomedicine approach in near future.Entities:
Keywords: Biocompatible; Butea monosperma; Cancer therapy; Drug delivery systems; Gold and silver nanoparticles; Green synthesis
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Year: 2015 PMID： 26042718 DOI： 10.1016/j.msec.2015.04.048
Source DB: PubMed Journal: Mater Sci Eng C Mater Biol Appl ISSN： 0928-4931 Impact factor: 7.328