| Literature DB >> 26041875 |
Stephanie Pfaender1, Stephanie Walter1, Daniel Todt1, Patrick Behrendt1, Juliane Doerrbecker1, Benno Wölk2,3, Michael Engelmann1, Ute Gravemann4, Axel Seltsam4, Joerg Steinmann5, Peter D Burbelo6, Frank Klawonn7,8, Karsten Feige9, Thomas Pietschmann1, Jessika-M V Cavalleri9, Eike Steinmann1.
Abstract
The recent discovery of hepatitis C virus (HCV)-related viruses in different animal species has raised new speculations regarding the origin of HCV and the possibility of a zoonotic source responsible for the endemic HCV transmission. As a consequence, these new findings prompt questions regarding the potential for cross-species transmissions of hepaciviruses. The closest relatives to HCV discovered to date are the non-primate hepaciviruses (NPHVs), which have been described to infect horses. To evaluate the risk of a potential zoonotic transmission, we analysed NPHV RNA and antibodies in humans with occupational exposure to horses in comparison with a low-risk group. Both groups were negative for NPHV RNA, even though low seroreactivities against various NPHV antigens could be detected irrespective of the group. In conclusion, we did not observe evidence of NPHV transmission between horses and humans.Entities:
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Year: 2015 PMID： 26041875 PMCID： PMC4857452 DOI： 10.1099/vir.0.000208
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891