Literature DB >> 26041737

First-in-Human Case Study: Multipotent Adult Progenitor Cells for Immunomodulation After Liver Transplantation.

Yorick Soeder1, Martin Loss1, Christian L Johnson1, James A Hutchinson1, Jan Haarer1, Norbert Ahrens1, Robert Offner1, Robert J Deans1, Gil Van Bokkelen1, Edward K Geissler1, Hans J Schlitt1, Marc H Dahlke2.   

Abstract

Mesenchymal stem cells and multipotent adult progenitor cells (MAPCs) have been proposed as novel therapeutics for solid organ transplant recipients with the aim of reducing exposure to pharmacological immunosuppression and its side effects. In the present study, we describe the clinical course of the first patient of the phase I, dose-escalation safety and feasibility study, MiSOT-I (Mesenchymal Stem Cells in Solid Organ Transplantation Phase I). After receiving a living-related liver graft, the patient was given one intraportal injection and one intravenous infusion of third-party MAPC in a low-dose pharmacological immunosuppressive background. Cell administration was found to be technically feasible; importantly, we found no evidence of acute toxicity associated with MAPC infusions. ©AlphaMed Press.

Entities:  

Keywords:  Cell therapy; Immunomodulation; Liver transplantation; Mesenchymal stem cells; Multipotent stem cells; Tolerance

Mesh：

Year:  2015        PMID： 26041737      PMCID： PMC4511146          DOI： 10.5966/sctm.2015-0002

Source DB:  PubMed          Journal:  Stem Cells Transl Med        ISSN： 2157-6564            Impact factor:   6.940


  10 in total

1.  Characterization of multipotent adult progenitor cells, a subpopulation of mesenchymal stem cells.

Authors:  M Reyes; C M Verfaillie
Journal:  Ann N Y Acad Sci       Date:  2001-06       Impact factor: 5.691

2.  Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.

Authors:  M Dominici; K Le Blanc; I Mueller; I Slaper-Cortenbach; Fc Marini; Ds Krause; Rj Deans; A Keating; Dj Prockop; Em Horwitz
Journal:  Cytotherapy       Date:  2006       Impact factor: 5.414

3.  Pre-clinical safety testing supporting clinical use of allogeneic multipotent adult progenitor cells.

Authors:  M Kovacsovics-Bankowski; K Mauch; A Raber; P R Streeter; R J Deans; R T Maziarz; W Van't Hof
Journal:  Cytotherapy       Date:  2008       Impact factor: 5.414

4.  Heart grafts tolerized through third-party multipotent adult progenitor cells can be retransplanted to secondary hosts with no immunosuppression.

Authors:  Elke Eggenhofer; Felix C Popp; Michael Mendicino; Paula Silber; Wouter Van't Hof; Philipp Renner; Martin J Hoogduijn; Jef Pinxteren; Nico van Rooijen; Edward K Geissler; Robert Deans; Hans J Schlitt; Marc H Dahlke
Journal:  Stem Cells Transl Med       Date:  2013-07-08       Impact factor: 6.940

5.  Safety and feasibility of third-party multipotent adult progenitor cells for immunomodulation therapy after liver transplantation--a phase I study (MISOT-I).

Authors:  Felix C Popp; Barbara Fillenberg; Elke Eggenhofer; Philipp Renner; Johannes Dillmann; Volker Benseler; Andreas A Schnitzbauer; James Hutchinson; Robert Deans; Deborah Ladenheim; Cheryl A Graveen; Florian Zeman; Michael Koller; Martin J Hoogduijn; Edward K Geissler; Hans J Schlitt; Marc H Dahlke
Journal:  J Transl Med       Date:  2011-07-28       Impact factor: 5.531

6.  Global Characterization and Genomic Stability of Human MultiStem, A Multipotent Adult Progenitor Cell.

Authors:  Sherry Boozer; Nicholas Lehman; Uma Lakshmipathy; Brad Love; Amy Raber; Anirban Maitra; Robert Deans; Mahendra S Rao; Anthony E Ting
Journal:  J Stem Cells       Date:  2009

7.  Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells.

Authors:  Federica Casiraghi; Nadia Azzollini; Paola Cassis; Barbara Imberti; Marina Morigi; Daniela Cugini; Regiane Aparecida Cavinato; Marta Todeschini; Samantha Solini; Aurelio Sonzogni; Norberto Perico; Giuseppe Remuzzi; Marina Noris
Journal:  J Immunol       Date:  2008-09-15       Impact factor: 5.422

8.  Mesenchymal stem cells can induce long-term acceptance of solid organ allografts in synergy with low-dose mycophenolate.

Authors:  F C Popp; E Eggenhofer; P Renner; P Slowik; S A Lang; H Kaspar; E K Geissler; P Piso; H J Schlitt; M H Dahlke
Journal:  Transpl Immunol       Date:  2008-08-30       Impact factor: 1.708

9.  Treatment-emergent adverse events after infusion of adherent stem cells: the MiSOT-I score for solid organ transplantation.

Authors:  Johannes Dillmann; Felix C Popp; Barbara Fillenberg; Florian Zeman; Elke Eggenhofer; Stefan Farkas; Marcus N Scherer; Michael Koller; Edward K Geissler; Robert Deans; Deborah Ladenheim; Martin Loss; Hans J Schlitt; Marc H Dahlke
Journal:  Trials       Date:  2012-11-15       Impact factor: 2.279

10.  Standardization of whole blood immune phenotype monitoring for clinical trials: panels and methods from the ONE study.

Authors:  Mathias Streitz; Tewfik Miloud; Michael Kapinsky; Michael R Reed; Robert Magari; Edward K Geissler; James A Hutchinson; Katrin Vogt; Stephan Schlickeiser; Anders Handrup Kverneland; Christian Meisel; Hans-Dieter Volk; Birgit Sawitzki
Journal:  Transplant Res       Date:  2013-10-25
  10 in total
  22 in total

1.  Steroid-Mediated Decrease in Blood Mesenchymal Stem Cells in Liver Transplant could Impact Long-Term Recovery.

Authors:  Nykia D Walker; Yasmine Mourad; Katherine Liu; Michael Buxhoeveden; Catherine Schoenberg; Jean D Eloy; Dorian J Wilson; Lloyd G Brown; Andrei Botea; Faraz Chaudhry; Steven J Greco; Nicholas M Ponzio; Nikolaos Pyrsopoulos; Baburao Koneru; Yuriy Gubenko; Pranela Rameshwar
Journal:  Stem Cell Rev Rep       Date:  2017-10       Impact factor: 5.739

Review 2.  Biological functions of mesenchymal stem cells and clinical implications.

Authors:  Abderrahim Naji; Masamitsu Eitoku; Benoit Favier; Frédéric Deschaseaux; Nathalie Rouas-Freiss; Narufumi Suganuma
Journal:  Cell Mol Life Sci       Date:  2019-05-04       Impact factor: 9.261

3.  How to Make Sense out of 75,000 Mesenchymal Stromal Cell Publications?

Authors:  Dina Mönch; Marlies E J Reinders; Marc H Dahlke; Martin J Hoogduijn
Journal:  Cells       Date:  2022-04-22       Impact factor: 7.666

4.  A Pilot Study of Mesenchymal Stem Cell Therapy for Acute Liver Allograft Rejection.

Authors:  Ming Shi; Zhenwen Liu; Ying Wang; Rounan Xu; Yanling Sun; Min Zhang; Xi Yu; Hongbo Wang; Lingzhan Meng; Haibin Su; Lei Jin; Fu-Sheng Wang
Journal:  Stem Cells Transl Med       Date:  2017-12       Impact factor: 6.940

5.  Safety and Tolerance of Donor-Derived Mesenchymal Stem Cells in Pediatric Living-Donor Liver Transplantation: The MYSTEP1 Study.

Authors:  Steffen Hartleif; Michael Schumm; Michaela Döring; Markus Mezger; Peter Lang; Marc H Dahlke; Joachim Riethmüller; Alfred Königsrainer; Rupert Handgretinger; Silvio Nadalin; Ekkehard Sturm
Journal:  Stem Cells Int       Date:  2017-06-27       Impact factor: 5.443

Review 6.  Concise Review: Mesenchymal Stromal Cell-Based Approaches for the Treatment of Acute Respiratory Distress and Sepsis Syndromes.

Authors:  Christian L Johnson; Yorick Soeder; Marc H Dahlke
Journal:  Stem Cells Transl Med       Date:  2017-01-09       Impact factor: 6.940

Review 7.  Mesenchymal Stromal Cells, a New Player in Reducing Complications From Liver Transplantation?

Authors:  Andrew Owen; Philip N Newsome
Journal:  Front Immunol       Date:  2020-06-19       Impact factor: 7.561

8.  The Delivery of Multipotent Adult Progenitor Cells to Extended Criteria Human Donor Livers Using Normothermic Machine Perfusion.

Authors:  Richard W Laing; Samantha Stubblefield; Lorraine Wallace; Valerie D Roobrouck; Ricky H Bhogal; Andrea Schlegel; Yuri L Boteon; Gary M Reynolds; Anthony E Ting; Darius F Mirza; Philip N Newsome; Hynek Mergental; Simon C Afford
Journal:  Front Immunol       Date:  2020-06-25       Impact factor: 7.561

Review 9.  Ex Vivo Mesenchymal Stem Cell Therapy to Regenerate Machine Perfused Organs.

Authors:  Christina Bogensperger; Julia Hofmann; Franka Messner; Thomas Resch; Andras Meszaros; Benno Cardini; Annemarie Weissenbacher; Rupert Oberhuber; Jakob Troppmair; Dietmar Öfner; Stefan Schneeberger; Theresa Hautz
Journal:  Int J Mol Sci       Date:  2021-05-15       Impact factor: 5.923

10.  Multipotent adult progenitor cells induce regulatory T cells and promote their suppressive phenotype via TGFβ and monocyte-dependent mechanisms.

Authors:  Alice Valentin-Torres; Cora Day; Jennifer M Taggart; Nicholas Williams; Samantha R Stubblefield; Valerie D Roobrouck; Jelle Beyens; Anthony E Ting
Journal:  Sci Rep       Date:  2021-06-30       Impact factor: 4.379
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