Seth M Armah1, Erick Boy2, Dan Chen1, Priscila Candal1, Manju B Reddy3. 1. Department of Food Science and Human Nutrition, Iowa State University, Ames, IA; and. 2. HarvestPlus/International Food Policy Research Institute, Washington, DC. 3. Department of Food Science and Human Nutrition, Iowa State University, Ames, IA; and mbreddy@iastate.edu.
Abstract
BACKGROUND:High phytate (HP) consumption is a concern in developing countries because of the high prevalence of iron deficiency in these countries. OBJECTIVE: We investigated whether habitual consumption of an HP diet reduces the inhibitory effect of phytate on nonheme-iron absorption. METHODS:Thirty-two nonanemic females, 18-35 y of age, with normal body mass index but with suboptimal iron stores (serum ferritin, ≤30 μg/L), were matched for serum ferritin concentration and randomly assigned toHP and low-phytate (LP) groups, in a parallel design study. Each subject consumed HP or LP foods with at least 2 of their daily meals for 8 wk, resulting in a change in phytate intake (from 718 to 1190 mg/d in the HP group and 623 to 385 mg/d in the LP group). The serum iron response over 4 h after a test meal containing 350 mg of phytate was measured at baseline and postintervention. Ferritin, transferrin receptor, and hepcidin concentrations were measured at baseline and 8 wk. RESULTS:Twenty-eight subjects completed the study (n = 14 per group). The serum iron response to the test meal increased in the HP group at postintervention, resulting in a 41% increase in the area under the curve (AUC; P < 0.0001). However, no effect was observed in the LP group (21% decrease in AUC; P = 0.76). The postintervention serum iron response was lower (P < 0.0001) in the LP group than in the HP group after controlling for the baseline serum iron response and hepcidin concentration, reflecting in a 64% lower AUC. CONCLUSIONS: We found that habitual consumption of an HP diet can reduce the negative effect of phytate on nonheme-iron absorption among young women with suboptimal iron stores. Future studies are needed to explore possible mechanisms. This trial was registered at clinicaltrials.gov as NCT02370940.
RCT Entities:
BACKGROUND: High phytate (HP) consumption is a concern in developing countries because of the high prevalence of iron deficiency in these countries. OBJECTIVE: We investigated whether habitual consumption of an HP diet reduces the inhibitory effect of phytate on nonheme-iron absorption. METHODS: Thirty-two nonanemic females, 18-35 y of age, with normal body mass index but with suboptimal iron stores (serum ferritin, ≤30 μg/L), were matched for serum ferritin concentration and randomly assigned to HP and low-phytate (LP) groups, in a parallel design study. Each subject consumed HP or LP foods with at least 2 of their daily meals for 8 wk, resulting in a change in phytate intake (from 718 to 1190 mg/d in the HP group and 623 to 385 mg/d in the LP group). The serum iron response over 4 h after a test meal containing 350 mg of phytate was measured at baseline and postintervention. Ferritin, transferrin receptor, and hepcidin concentrations were measured at baseline and 8 wk. RESULTS: Twenty-eight subjects completed the study (n = 14 per group). The serum iron response to the test meal increased in the HP group at postintervention, resulting in a 41% increase in the area under the curve (AUC; P < 0.0001). However, no effect was observed in the LP group (21% decrease in AUC; P = 0.76). The postintervention serum iron response was lower (P < 0.0001) in the LP group than in the HP group after controlling for the baseline serum iron response and hepcidin concentration, reflecting in a 64% lower AUC. CONCLUSIONS: We found that habitual consumption of an HP diet can reduce the negative effect of phytate on nonheme-iron absorption among young women with suboptimal iron stores. Future studies are needed to explore possible mechanisms. This trial was registered at clinicaltrials.gov as NCT02370940.
Authors: Tripti Singhal; C Tara Satyavathi; S P Singh; M Mallik; N Anuradha; S Mukesh Sankar; C Bharadwaj; Nirupma Singh Journal: Physiol Mol Biol Plants Date: 2022-04-27
Authors: E Rochelle Werner; Charles D Arnold; Bess L Caswell; Lora L Iannotti; Chessa K Lutter; Kenneth M Maleta; Christine P Stewart Journal: Curr Dev Nutr Date: 2022-05-13
Authors: Nicole M Delimont; Benjamin B Katz; Nicole M Fiorentino; Katheryne A Kimmel; Mark D Haub; Sara K Rosenkranz; John M Tomich; Brian L Lindshield Journal: Curr Dev Nutr Date: 2019-04-20
Authors: Nicole M Delimont; Nicole M Fiorentino; Katheryne A Kimmel; Mark D Haub; Sara K Rosenkranz; Brian L Lindshield Journal: Curr Dev Nutr Date: 2017-09-11