Literature DB >> 26040468

Amyloid in dementia associated with familial FTLD: not an innocent bystander.

Georges Naasan1, Gil D Rabinovici1, Pia Ghosh1, Jonathan D Elofson1, Bruce L Miller1, Giovanni Coppola2, Anna Karydas1, Jamie Fong1, David Perry1, Suzee E Lee1, Jennifer S Yokoyama1, William W Seeley1, Joel H Kramer1, Michael W Weiner3, Norbert Schuff3, William J Jagust4, Lea T Grinberg1, Mochtar Pribadi2, Zhongan Yang2, Renee Sears2, Eric Klein2, Kevin Wojta2, Howard J Rosen1.   

Abstract

Patients with frontotemporal lobar degeneration (FTLD) can show superimposed amyloid pathology, though the impact of amyloid on the clinical presentation of FTLD is not well characterized. This cross-sectional case-control study compared clinical features, fluorodeoxyglucose-positron emission tomography metabolism and gray matter volume loss in 30 patients with familial FTLD in whom amyloid status was confirmed with autopsy or Pittsburgh compound B-PET. Compared to the amyloid-negative patients, the amyloid-positive patients performed significantly worse on several cognitive tests and showed hypometabolism and volume loss in more temporoparietal regions. Our results suggest that in FTLD amyloid positivity is associated with a more Alzheimer's disease-like pattern of neurodegeneration.

Entities:  

Keywords:  Alzheimer’s disease; FDG-PET; MRI; amyloid; frontotemporal dementia

Mesh：

Substances：

Year:  2015        PMID： 26040468      PMCID： PMC4662906          DOI： 10.1080/13554794.2015.1046458

Source DB:  PubMed          Journal:  Neurocase        ISSN： 1355-4794            Impact factor:   0.881


  41 in total

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