Michaela Kozakova1, Carmela Morizzo, Daniela Guarino, Giovanni Federico, Mario Miccoli, Cristina Giannattasio, Carlo Palombo. 1. aDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa bEsaote SpA, Genova cDepartment of Surgical, Medical, Molecular and Critical Care Pathology dDepartment of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa eHealth Science Department, University of Milano-Bicocca, Milan, Italy.
Abstract
OBJECTIVE: Segmental carotid-femoral pulse-wave velocity (PWV) is a gold standard method for arterial stiffness assessment; recently, a local carotid PWV measurement by ultrasound has been developed. The present study compared the impact of age and established risk factors on carotid and carotid-femoral PWV. METHODS: Three hundred and seven volunteers (167 men; age from 15 to 78 years) free of cardiovascular disease, diabetes, antihypertensive and lipid-lowering treatment underwent sequential measurement of carotid and carotid-femoral PWV. RESULTS: In the entire study population, both carotid and carotid-femoral PWV were independently associated mainly with age and blood pressure. In individuals more than 50 years old (N = 132, 80 men), carotid-femoral PWV, but not carotid PWV, was also associated with high-density lipoprotein (HDL)-cholesterol and fasting glucose. The annual increase in carotid and carotid-femoral PWV was similar (0.087 ± 0.004 and 0.090 ± 0.005 m/s, respectively; P = 0.69). Carotid PWV increased with age more rapidly in women than in men (0.099 ± 0.005 vs. 0.076 ± 0.005 m/s per year, P < 0.005), whereas carotid-femoral PWV showed a steeper increase in individuals more than 50 years old than individuals aged 50 years or less (0.150 ± 0.019 vs. 0.088 ± 0.007 m/s per year, P = 0.001). CONCLUSION: In apparently healthy population, both carotid and carotid-femoral PWV were influenced above all by age and blood pressure. Other established cardiovascular risk factors had a limited impact only on carotid-femoral PWV of older individuals. The age-related increase in carotid and carotid-femoral PWV seemed to follow different patterns; increase in carotid PWV showed age-sex interaction, being steeper in women, whereas increase in carotid-femoral PWV was more prominent in older individuals.
OBJECTIVE: Segmental carotid-femoral pulse-wave velocity (PWV) is a gold standard method for arterial stiffness assessment; recently, a local carotid PWV measurement by ultrasound has been developed. The present study compared the impact of age and established risk factors on carotid and carotid-femoral PWV. METHODS: Three hundred and seven volunteers (167 men; age from 15 to 78 years) free of cardiovascular disease, diabetes, antihypertensive and lipid-lowering treatment underwent sequential measurement of carotid and carotid-femoral PWV. RESULTS: In the entire study population, both carotid and carotid-femoral PWV were independently associated mainly with age and blood pressure. In individuals more than 50 years old (N = 132, 80 men), carotid-femoral PWV, but not carotid PWV, was also associated with high-density lipoprotein (HDL)-cholesterol and fasting glucose. The annual increase in carotid and carotid-femoral PWV was similar (0.087 ± 0.004 and 0.090 ± 0.005 m/s, respectively; P = 0.69). Carotid PWV increased with age more rapidly in women than in men (0.099 ± 0.005 vs. 0.076 ± 0.005 m/s per year, P < 0.005), whereas carotid-femoral PWV showed a steeper increase in individuals more than 50 years old than individuals aged 50 years or less (0.150 ± 0.019 vs. 0.088 ± 0.007 m/s per year, P = 0.001). CONCLUSION: In apparently healthy population, both carotid and carotid-femoral PWV were influenced above all by age and blood pressure. Other established cardiovascular risk factors had a limited impact only on carotid-femoral PWV of older individuals. The age-related increase in carotid and carotid-femoral PWV seemed to follow different patterns; increase in carotid PWV showed age-sex interaction, being steeper in women, whereas increase in carotid-femoral PWV was more prominent in older individuals.
Authors: Mónica Vázquez-Del Mercado; Eduardo Gomez-Bañuelos; Efrain Chavarria-Avila; Ernesto Cardona-Muñoz; Carlos Ramos-Becerra; Adrián Alanis-Sanchez; David Cardona-Muller; Fernando Grover-Paez; Felipe de J Perez-Vazquez; Rosa-Elena Navarro-Hernandez; Jorge M Valadez-Soto; Adan A Saldaña-Millan; Lorena Gonzalez-Rosas; Gabriel Ramos-Lopez; Marcelo H Petri; Magnus Bäck Journal: Medicine (Baltimore) Date: 2017-08 Impact factor: 1.889
Authors: Tokuhisa Uejima; Frank D Dunstan; Eloisa Arbustini; Krystyna Łoboz-Grudzień; Alun D Hughes; Scipione Carerj; Valentina Favalli; Francesco Antonini-Canterin; Olga Vriz; Dragos Vinereanu; Jose L Zamorano; Bogdan A Popescu; Arturo Evangelista; Patrizio Lancellotti; Georges Lefthériotis; Michaela Kozakova; Carlo Palombo; Alan G Fraser Journal: J Hum Hypertens Date: 2019-08-21 Impact factor: 3.012