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Literature DB >> 26039210

Improved immune recovery after transplantation of TCRαβ/CD19-depleted allografts from haploidentical donors in pediatric patients.

P Lang¹, T Feuchtinger¹, H-M Teltschik¹, W Schwinger², P Schlegel¹, M Pfeiffer¹, M Schumm¹, A-M Lang¹, B Lang¹, C P Schwarze¹, M Ebinger¹, C Urban², R Handgretinger¹.

Abstract

Immune recovery was retrospectively analyzed in a cohort of 41 patients with acute leukemia, myelodysplastic syndrome and nonmalignant diseases, who received αβ T- and B-cell-depleted allografts from haploidentical family donors. Conditioning regimens consisted of fludarabine or clofarabine, thiotepa, melphalan and serotherapy with OKT3 or ATG-Fresenius. Graft manipulation was carried out with anti-TCRαβ and anti-CD19 Abs and immunomagnetic microbeads. The γδ T cells and natural killer cells remained in the grafts. Primary engraftment occurred in 88%, acute GvHD (aGvHD) grades II and III-IV occurred in 10% and 15%, respectively. Immune recovery data were available in 26 patients and comparable after OKT3 (n=7) or ATG-F (n=19). Median time to reach >100 CD3+ cells/μL, >200 CD19+ cells/μL and >200 CD56+ cells/μL for the whole group was 13, 127 and 12.5 days, respectively. Compared with a historical control group of patients with CD34+ selected grafts, significantly higher cell numbers were found for CD3+ at days +30 and +90 (267 vs 27 and 397 vs 163 cells/μL), for CD3+4+ at day +30 (58 vs 11 cells/μL) and for CD56+ at day +14 (622 vs 27 cells/μL). The clinical impact of this accelerated immune recovery will be evaluated in an ongoing prospective multicenter trial.

Entities: Chemical Disease Gene Species

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Year: 2015 PMID： 26039210 DOI： 10.1038/bmt.2015.87

Source DB: PubMed Journal: Bone Marrow Transplant ISSN： 0268-3369 Impact factor: 5.483

12 in total

1. Determination of residual T- and B-cell content after immunomagnetic depletion: proposal for flow cytometric analysis and results from 103 separations.

Authors: M Schumm; R Handgretinger; M Pfeiffer; T Feuchtinger; S Kuci; C Faul; W Vogel; W Bethge; P Lang
Journal: Cytotherapy Date: 2006 Impact factor: 5.414

2. Human gammadelta T cells from G-CSF-mobilized donors retain strong tumoricidal activity and produce immunomodulatory cytokines after clinical-scale isolation.

Authors: Mario Otto; Raymond C Barfield; Rekha Iyengar; Janet Gatewood; Ingo Müller; Martha S Holladay; Jim Houston; Wing Leung; Rupert Handgretinger
Journal: J Immunother Date: 2005 Jan-Feb Impact factor: 4.456

3. Megadose transplantation of purified peripheral blood CD34(+) progenitor cells from HLA-mismatched parental donors in children.

Authors: R Handgretinger; T Klingebiel; P Lang; M Schumm; S Neu; A Geiselhart; P Bader; P G Schlegel; J Greil; D Stachel; R J Herzog; D Niethammer
Journal: Bone Marrow Transplant Date: 2001-04 Impact factor: 5.483

Review 4. Haploidentical hematopoietic transplantation: current status and future perspectives.

Authors: Yair Reisner; David Hagin; Massimo F Martelli
Journal: Blood Date: 2011-09-14 Impact factor: 22.113

5. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors.

Authors: H Glucksberg; R Storb; A Fefer; C D Buckner; P E Neiman; R A Clift; K G Lerner; E D Thomas
Journal: Transplantation Date: 1974-10 Impact factor: 4.939

6. Long-term outcome after haploidentical stem cell transplantation in children.

Authors: Peter Lang; Johann Greil; Peter Bader; Rupert Handgretinger; Thomas Klingebiel; Michael Schumm; Paul-Gerhard Schlegel; Tobias Feuchtinger; Matthias Pfeiffer; Hans Scheel-Walter; Monika Führer; David Martin; Dietrich Niethammer
Journal: Blood Cells Mol Dis Date: 2004 Nov-Dec Impact factor: 3.039

7. Haploidentical stem cell transplantation for children with acute leukaemia.

Authors: David I Marks; Navin Khattry; Michelle Cummins; Nicholas Goulden; Ann Green; John Harvey; Linda P Hunt; Leigh Keen; Stephen P Robinson; Colin G Steward; Jacqueline M Cornish
Journal: Br J Haematol Date: 2006-07 Impact factor: 6.998

8. Partially matched related donor peripheral blood progenitor cell transplantation in paediatric patients adding fludarabine and anti-lymphocyte gamma-globulin.

Authors: M Ortín; R Raj; E Kinning; M Williams; P J Darbyshire
Journal: Bone Marrow Transplant Date: 2002-09 Impact factor: 5.483

9. Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse.

Authors: Franco Aversa; Adelmo Terenzi; Antonio Tabilio; Franca Falzetti; Alessandra Carotti; Stelvio Ballanti; Rita Felicini; Flavio Falcinelli; Andrea Velardi; Loredana Ruggeri; Teresa Aloisi; Jean Pierre Saab; Antonella Santucci; Katia Perruccio; Maria Paola Martelli; Cristina Mecucci; Yair Reisner; Massimo F Martelli
Journal: J Clin Oncol Date: 2005-03-07 Impact factor: 44.544

10. Results and factors influencing outcome after fully haploidentical hematopoietic stem cell transplantation in children with very high-risk acute lymphoblastic leukemia: impact of center size: an analysis on behalf of the Acute Leukemia and Pediatric Disease Working Parties of the European Blood and Marrow Transplant group.

Authors: Thomas Klingebiel; Jacqueline Cornish; Myriam Labopin; Franco Locatelli; Philippe Darbyshire; Rupert Handgretinger; Adriana Balduzzi; Joanna Owoc-Lempach; Franca Fagioli; Reuven Or; Christina Peters; Franco Aversa; Emmanuelle Polge; Giorgio Dini; Vanderson Rocha
Journal: Blood Date: 2009-12-29 Impact factor: 22.113

46 in total

1. Mismatched related vs matched unrelated donors in TCRαβ/CD19-depleted HSCT for primary immunodeficiencies.

Authors: Alexandra Laberko; Elvira Sultanova; Elena Gutovskaya; Irina Shipitsina; Larisa Shelikhova; Elena Kurnikova; Yakov Muzalevskii; Alexei Kazachenok; Dmitriy Pershin; Kirill Voronin; Anna Shcherbina; Michael Maschan; Alexey Maschan; Dmitry Balashov
Journal: Blood Date: 2019-11-14 Impact factor: 22.113

2. Haploidentical hematopoietic stem cell transplantation in children with high-risk hematologic malignancies: outcomes with two different strategies for GvHD prevention. Ex vivo T-cell depletion and post-transplant cyclophosphamide: 10 years of experience at a single center.

Authors: G Dufort; L Castillo; S Pisano; M Castiglioni; P Carolina; I Andrea; E Simon; S Zuccolo; M Schelotto; F Morosini; I Pereira; P Amarillo; A Silveira; L Guerrero; V Ferreira; A Tiscornia; R Mezzano; F Lemos; B Boggia; A Quarnetti; J Decaro; A Dabezies
Journal: Bone Marrow Transplant Date: 2016-06-06 Impact factor: 5.483

3. Selective T-cell depletion targeting CD45RA reduces viremia and enhances early T-cell recovery compared with CD3-targeted T-cell depletion.

Authors: Brandon M Triplett; Brad Muller; Guolian Kang; Ying Li; Shane J Cross; Joseph Moen; Lea Cunningham; William Janssen; Ewelina Mamcarz; David R Shook; Ashok Srinivasan; John Choi; Randall T Hayden; Wing Leung
Journal: Transpl Infect Dis Date: 2018-01-16 Impact factor: 2.228

4. The next step toward GMP-grade production of engineered immune cells.

Authors: Guido J J Kierkels; Trudy Straetemans; Moniek A de Witte; Jürgen Kuball
Journal: Oncoimmunology Date: 2015-08-27 Impact factor: 8.110

Review 5. Selected biological issues affecting relapse after stem cell transplantation: role of T-cell impairment, NK cells and intrinsic tumor resistance.

Authors: Marcel van den Brink; Markus Uhrberg; Lorenz Jahn; John F DiPersio; Michael A Pulsipher
Journal: Bone Marrow Transplant Date: 2018-01-24 Impact factor: 5.483

6. Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection.

Authors: Sarina Ravens; Christian Schultze-Florey; Solaiman Raha; Inga Sandrock; Melanie Drenker; Linda Oberdörfer; Annika Reinhardt; Inga Ravens; Maleen Beck; Robert Geffers; Constantin von Kaisenberg; Michael Heuser; Felicitas Thol; Arnold Ganser; Reinhold Förster; Christian Koenecke; Immo Prinz
Journal: Nat Immunol Date: 2017-02-20 Impact factor: 25.606