Claudio Babiloni1, Claudio Del Percio2, Fabrizio Vecchio3, Fabio Sebastiano4, Giancarlo Di Gennaro4, Pier P Quarato4, Roberta Morace4, Luigi Pavone4, Andrea Soricelli5, Giuseppe Noce6, Vincenzo Esposito7, Paolo Maria Rossini8, Vittorio Gallese9, Giovanni Mirabella7. 1. Department of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy; IRCCS S. Raffaele Pisana, Rome, Italy. 2. IRCCS S. Raffaele Pisana, Rome, Italy. Electronic address: claudio.delpercio@uniroma1.it. 3. IRCCS S. Raffaele Pisana, Rome, Italy. 4. IRCCS Neuromed, Pozzilli, IS, Italy. 5. IRCCS SDN, SDN Foundation, Naples, Italy; Department of Studies of Institutions and Territorial Systems, University of Naples Parthenope, Naples, Italy. 6. IRCCS SDN, SDN Foundation, Naples, Italy. 7. Department of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy; IRCCS Neuromed, Pozzilli, IS, Italy. 8. IRCCS S. Raffaele Pisana, Rome, Italy; Neurology, Catholic University of Sacro Cuore, Rome, Italy. 9. Department of Neuroscience, University of Parma, Italy.
Abstract
OBJECTIVE: In the present study, we tested the hypothesis that both movement execution and observation induce parallel modulations of alpha, beta, and gamma electrocorticographic (ECoG) rhythms in primary somatosensory (Brodmann area 1-2, BA1-2), primary motor (BA4), ventral premotor (BA6), and prefrontal (BA44 and BA45, part of putative human mirror neuron system underlying the understanding of actions of other people) areas. METHODS: ECoG activity was recorded in drug-resistant epileptic patients during the execution of actions to reach and grasp common objects according to their affordances, as well as during the observation of the same actions performed by an experimenter. RESULTS: Both action execution and observation induced a desynchronization of alpha and beta rhythms in BA1-2, BA4, BA6, BA44 and BA45, which was generally higher in amplitude during the former than the latter condition. Action execution also induced a major synchronization of gamma rhythms in BA4 and BA6, again more during the execution of an action than during its observation. CONCLUSION: Human primary sensorimotor, premotor, and prefrontal areas do generate alpha, beta, and gamma rhythms and differently modulate them during action execution and observation. Gamma rhythms of motor areas are especially involved in action execution. SIGNIFICANCE: Oscillatory activity of neural populations in sensorimotor, premotor and prefrontal (part of human mirror neuron system) areas represents and distinguishes own actions from those of other people. This methodological approach might be used for a neurophysiological diagnostic imaging of social cognition in epileptic patients.
OBJECTIVE: In the present study, we tested the hypothesis that both movement execution and observation induce parallel modulations of alpha, beta, and gamma electrocorticographic (ECoG) rhythms in primary somatosensory (Brodmann area 1-2, BA1-2), primary motor (BA4), ventral premotor (BA6), and prefrontal (BA44 and BA45, part of putative human mirror neuron system underlying the understanding of actions of other people) areas. METHODS: ECoG activity was recorded in drug-resistant epilepticpatients during the execution of actions to reach and grasp common objects according to their affordances, as well as during the observation of the same actions performed by an experimenter. RESULTS: Both action execution and observation induced a desynchronization of alpha and beta rhythms in BA1-2, BA4, BA6, BA44 and BA45, which was generally higher in amplitude during the former than the latter condition. Action execution also induced a major synchronization of gamma rhythms in BA4 and BA6, again more during the execution of an action than during its observation. CONCLUSION:Human primary sensorimotor, premotor, and prefrontal areas do generate alpha, beta, and gamma rhythms and differently modulate them during action execution and observation. Gamma rhythms of motor areas are especially involved in action execution. SIGNIFICANCE: Oscillatory activity of neural populations in sensorimotor, premotor and prefrontal (part of human mirror neuron system) areas represents and distinguishes own actions from those of other people. This methodological approach might be used for a neurophysiological diagnostic imaging of social cognition in epilepticpatients.
Authors: Yvonne M Fonken; Jochem W Rieger; Elinor Tzvi; Nathan E Crone; Edward Chang; Josef Parvizi; Robert T Knight; Ulrike M Krämer Journal: J Neurophysiol Date: 2016-02-10 Impact factor: 2.714
Authors: Anat Perry; Jennifer Stiso; Edward F Chang; Jack J Lin; Josef Parvizi; Robert T Knight Journal: Cereb Cortex Date: 2018-03-01 Impact factor: 5.357
Authors: Alexander B Remsik; Peter L E van Kan; Shawna Gloe; Klevest Gjini; Leroy Williams; Veena Nair; Kristin Caldera; Justin C Williams; Vivek Prabhakaran Journal: Front Hum Neurosci Date: 2022-07-06 Impact factor: 3.473