Yizhi Liu1, Nathan Congdon2, Weirong Chen3, Yuzhen Jiang4. 1. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, China yizhi_liu@aliyun.com. 2. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, China Orbis International, New York, USA Queen's University Belfast, Belfast, UK. 3. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, China. 4. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, China Moorfields Eye Hospital, London, UK.