Stephen E Kirkby1,2, Don Hayes3,4, Jonathan P Parsons4, Clayton E Wisely3, Ben Kopp3, Karen S McCoy3, John G Mastronarde4. 1. Section of Pulmonary Medicine, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA. stephen.kirkby@nationwidechildrens.org. 2. Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, The Ohio State University, Columbus, OH, USA. stephen.kirkby@nationwidechildrens.org. 3. Section of Pulmonary Medicine, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA. 4. Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
Abstract
BACKGROUND: Exercise-induced bronchoconstriction (EIB) has not been well studied in cystic fibrosis (CF), and eucapnic voluntary hyperventilation (EVH) testing has not been used as an objective assessment of EIB in CF to date. METHODS: A prospective cohort pilot study was completed where standard EVH testing was completed by 10 CF patients with forced expiratory volume in 1 s (FEV1) ≥70% of predicted. All patients also completed a cardiopulmonary exercise test (CPET) with pre- and post-CPET spirometry as a comparative method of detecting EIB. RESULTS: No adverse events occurred with EVH testing. A total of 20% (2/10) patients were diagnosed with EIB by means of EVH. Both patients had clinical symptoms consistent with EIB. No patient had a CPET-based exercise challenge consistent with EIB. CONCLUSIONS: EVH testing was safe and effective in the objective assessment for EIB in patients with CF who had well-preserved lung function. It may be a more sensitive method of detecting EIB then exercise challenge.
BACKGROUND: Exercise-induced bronchoconstriction (EIB) has not been well studied in cystic fibrosis (CF), and eucapnic voluntary hyperventilation (EVH) testing has not been used as an objective assessment of EIB in CF to date. METHODS: A prospective cohort pilot study was completed where standard EVH testing was completed by 10 CF patients with forced expiratory volume in 1 s (FEV1) ≥70% of predicted. All patients also completed a cardiopulmonary exercise test (CPET) with pre- and post-CPET spirometry as a comparative method of detecting EIB. RESULTS: No adverse events occurred with EVH testing. A total of 20% (2/10) patients were diagnosed with EIB by means of EVH. Both patients had clinical symptoms consistent with EIB. No patient had a CPET-based exercise challenge consistent with EIB. CONCLUSIONS:EVH testing was safe and effective in the objective assessment for EIB in patients with CF who had well-preserved lung function. It may be a more sensitive method of detecting EIB then exercise challenge.
Authors: Jonathan P Parsons; Teal S Hallstrand; John G Mastronarde; David A Kaminsky; Kenneth W Rundell; James H Hull; William W Storms; John M Weiler; Fern M Cheek; Kevin C Wilson; Sandra D Anderson Journal: Am J Respir Crit Care Med Date: 2013-05-01 Impact factor: 21.405
Authors: Janne Burman; Varpu Elenius; Heikki Lukkarinen; Tom Kuusela; Mika J Mäkelä; Olli Kesti; Katri Väätäinen; Maria Maunula; Sami Remes; Tuomas Jartti Journal: Clin Physiol Funct Imaging Date: 2020-06-26 Impact factor: 2.273