| Literature DB >> 26036940 |
Isabelle Boileau1, Rachel F Tyndale2, Belinda Williams3, Esmaeil Mansouri3, Duncan J Westwood4, Bernard Le Foll5, Pablo M Rusjan6, Romina Mizrahi7, Vincenzo De Luca8, Qian Zhou9, Alan A Wilson10, Sylvain Houle10, Stephen J Kish11, Junchao Tong12.
Abstract
The common functional single-nucleotide polymorphism (rs324420, C385A) of the endocannabinoid inactivating enzyme fatty acid amide hydrolase (FAAH) has been associated with anxiety disorder relevant phenotype and risk for addictions. Here, we tested whether the FAAH polymorphism affects in vivo binding of the FAAH positron emission tomography (PET) probe [(11)C]CURB ([(11)C-carbonyl]-6-hydroxy-[1,10-biphenyl]-3-yl cyclohexylcarbamate (URB694)). Participants (n=24) completed one [(11)C]CURB/PET scan and were genotyped for rs324420. Relative to C/C (58%), A-allele carriers (42%) had 23% lower [(11)C]CURB binding (λk3) in brain. We report evidence that the genetic variant rs324420 in FAAH is associated with measurable differences in brain FAAH binding as per PET [(11)C]CURB measurement.Entities:
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Year: 2015 PMID： 26036940 PMCID： PMC4527995 DOI： 10.1038/jcbfm.2015.119
Source DB: PubMed Journal: J Cereb Blood Flow Metab ISSN： 0271-678X Impact factor: 6.200