M Guedes-Marques1, C Romãozinho2, L Santos2, F Macário2, R Alves2, A Mota3. 1. Department of Nephrology, Centro Hospitalar e Universitário de Coimbra-Hospital Geral, Coimbra, Portugal; Department of Urology and Kidney Transplantation, Centro Hospitalar e Universitário de Coimbra-Hospital Geral, Coimbra, Portugal. Electronic address: mariaguedesmarques@gmail.com. 2. Department of Nephrology, Hospitais Universidade de Coimbra, Coimbra, Portugal; Department of Urology and Kidney Transplantation, Centro Hospitalar e Universitário de Coimbra-Hospital Geral, Coimbra, Portugal. 3. Department of Urology and Kidney Transplantation, Centro Hospitalar e Universitário de Coimbra-Hospital Geral, Coimbra, Portugal.
Abstract
INTRODUCTION: Several factors have an impact on allograft survival but many are still controversial. In this study we investigated the effect of multiple factors on early renal graft function as an effort to find new tools to improve. MATERIAL AND METHODS: This was a transversal study of 64 patients who underwent kidney transplantation during the first semester of 2013. Demographic, clinical, and laboratory data were collected and analyzed. We used SPSS 20.0. Univariate analysis through nonparametric tests and multivariate analysis through linear regression were made. RESULTS: Regarding the donor, age (β = 1.581; P = .003) and stroke as cause of death (P = .044) were associated with a higher creatinine level. Concerning the recipient, age (β = 0.963; P = .001) as well as the difference between the candidate and the donor (β = 1.203; P = .000), black race (P = .032/.000), male gender (P = .027/.046), vasculopathic end-stage renal disease (ESRD; P = .050), hemodialysis (HD) modality (P = .001/.033), HD session before surgery (P = .005), body mass index (BMI) >25 kg/m(2) (P = .043), hypoalbuminemia (β = -0.280/-0.076; P = .029/.046), and anemia (β = -0.361; P = .032) were also associated with a higher creatinine level. Living donor transplant (P = .000/.043), instant diuresis (P = .000/.021), and post-transplantation higher blood pressure (BP; systolic BP [SBP] β = -0.452; P = .021 and diastolic BP [DBP] β = -0.318; P = .033) were associate with lower creatinine values. Overall, 87.6% of the renal function markers after the first semester were explained by the multiple factors above mentioned. CONCLUSIONS: Our findings are of practical clinical interest because nutritional status, hemoglobin, albumin, and BP are some of the objective measurable and modifiable parameters of which management may improve renal graft function.
INTRODUCTION: Several factors have an impact on allograft survival but many are still controversial. In this study we investigated the effect of multiple factors on early renal graft function as an effort to find new tools to improve. MATERIAL AND METHODS: This was a transversal study of 64 patients who underwent kidney transplantation during the first semester of 2013. Demographic, clinical, and laboratory data were collected and analyzed. We used SPSS 20.0. Univariate analysis through nonparametric tests and multivariate analysis through linear regression were made. RESULTS: Regarding the donor, age (β = 1.581; P = .003) and stroke as cause of death (P = .044) were associated with a higher creatinine level. Concerning the recipient, age (β = 0.963; P = .001) as well as the difference between the candidate and the donor (β = 1.203; P = .000), black race (P = .032/.000), male gender (P = .027/.046), vasculopathic end-stage renal disease (ESRD; P = .050), hemodialysis (HD) modality (P = .001/.033), HD session before surgery (P = .005), body mass index (BMI) >25 kg/m(2) (P = .043), hypoalbuminemia (β = -0.280/-0.076; P = .029/.046), and anemia (β = -0.361; P = .032) were also associated with a higher creatinine level. Living donor transplant (P = .000/.043), instant diuresis (P = .000/.021), and post-transplantation higher blood pressure (BP; systolic BP [SBP] β = -0.452; P = .021 and diastolic BP [DBP] β = -0.318; P = .033) were associate with lower creatinine values. Overall, 87.6% of the renal function markers after the first semester were explained by the multiple factors above mentioned. CONCLUSIONS: Our findings are of practical clinical interest because nutritional status, hemoglobin, albumin, and BP are some of the objective measurable and modifiable parameters of which management may improve renal graft function.
Authors: Aniruddha Srivastava; Joshua Bodnar; Fauzia Osman; Margaret R Jorgenson; Brad C Astor; Didier A Mandelbrot; Sandesh Parajuli Journal: Kidney Int Rep Date: 2020-09-19