| Literature DB >> 26036437 |
Mohsen Khosravi-Maharlooei1, Ensiyeh Hajizadeh-Saffar1, Yaser Tahamtani1, Mohsen Basiri1, Leila Montazeri1, Keynoosh Khalooghi1, Mohammad Kazemi Ashtiani1, Ali Farrokhi1, Nasser Aghdami1, Anavasadat Sadr Hashemi Nejad1, Mohammad-Bagher Larijani1, Nico De Leu1, Harry Heimberg1, Xunrong Luo1, Hossein Baharvand2.
Abstract
Over the past decades, tremendous efforts have been made to establish pancreatic islet transplantation as a standard therapy for type 1 diabetes. Recent advances in islet transplantation have resulted in steady improvements in the 5-year insulin independence rates for diabetic patients. Here we review the key challenges encountered in the islet transplantation field which include islet source limitation, sub-optimal engraftment of islets, lack of oxygen and blood supply for transplanted islets, and immune rejection of islets. Additionally, we discuss possible solutions for these challenges.Entities:
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Year: 2015 PMID： 26036437 DOI： 10.1530/EJE-15-0094
Source DB: PubMed Journal: Eur J Endocrinol ISSN： 0804-4643 Impact factor: 6.664