Jason H Peragallo1, Elena Bitrian, Mark J Kupersmith, Fritz Zimprich, Thomas J Whittaker, Michael S Lee, Beau B Bruce. 1. Departments of Ophthalmology (JHP, BBB), Pediatrics (JHP), and Neurology (BBB), Emory University, Atlanta, Georgia; Department of Ophthalmology and Visual Neurosciences (EB, MSL), University of Minnesota, Minneapolis, Minnesota; New York Eye and Ear Infirmary and INN at Roosevelt Hospital (MJK), New York, New York; Department of Neuro-ophthalmology (MJK), New York Eye and Ear Infirmary of Mount Sinai, New York, New York; Department of Neurology (FZ), Medical University of Vienna, Vienna, Austria; Department of Ophthalmology (TJW), University of Kansas Medical Center, Kansas City, Kansas; and Department of Epidemiology (B.B.B.), Rollins School of Public Health and Laney Graduate School, Emory University, Atlanta, Georgia.
Abstract
BACKGROUND: The demographic associations among patients presenting with myasthenia gravis with only ocular manifestations (OMG) is not clear. METHODS: In this 5-center case series, we collected the race, gender, and age at diagnosis of patients diagnosed with myasthenia gravis who had no signs or symptoms of generalized myasthenia gravis (GMG). An a priori sample size calculation determined that 140 patients were required to accept that there was a ≤10-year difference in mean age (equivalence testing: power 90%, α = 0.05). Robust Bayesian analysis and linear regression were applied to evaluate whether age differed by gender or race. RESULTS: Of 433 patients included, 258 (60%) were men. Mean age among men was 57 years (SD = 19) and 52 years (SD = 21) among women. The 95% credible interval (CI) (Bayesian equivalent of confidence interval) was 0.8-8.7 years for mean age, and there was a 99.6% probability that the mean difference in age between sexes was <10 years. Race was documented in 376 (68 [18%] non-Caucasian). Caucasians were 17.3 years older than non-Caucasians at diagnosis (95% CI, 12.2-22.3 y; P < 0.001) controlling for gender. There was no additive interaction of gender and race (P = 0.74). There was a bimodal distribution for women peaking around 30 and 60 years. Men had a left skewed unimodal age distribution peaking at age 70. CONCLUSIONS: The distribution of age at presentation in patients with OMG is different between men and women, similar to GMG. Non-Caucasian patients tend to develop OMG at a younger age.
BACKGROUND: The demographic associations among patients presenting with myasthenia gravis with only ocular manifestations (OMG) is not clear. METHODS: In this 5-center case series, we collected the race, gender, and age at diagnosis of patients diagnosed with myasthenia gravis who had no signs or symptoms of generalized myasthenia gravis (GMG). An a priori sample size calculation determined that 140 patients were required to accept that there was a ≤10-year difference in mean age (equivalence testing: power 90%, α = 0.05). Robust Bayesian analysis and linear regression were applied to evaluate whether age differed by gender or race. RESULTS: Of 433 patients included, 258 (60%) were men. Mean age among men was 57 years (SD = 19) and 52 years (SD = 21) among women. The 95% credible interval (CI) (Bayesian equivalent of confidence interval) was 0.8-8.7 years for mean age, and there was a 99.6% probability that the mean difference in age between sexes was <10 years. Race was documented in 376 (68 [18%] non-Caucasian). Caucasians were 17.3 years older than non-Caucasians at diagnosis (95% CI, 12.2-22.3 y; P < 0.001) controlling for gender. There was no additive interaction of gender and race (P = 0.74). There was a bimodal distribution for women peaking around 30 and 60 years. Men had a left skewed unimodal age distribution peaking at age 70. CONCLUSIONS: The distribution of age at presentation in patients with OMG is different between men and women, similar to GMG. Non-Caucasian patients tend to develop OMG at a younger age.
Authors: Djingri Labodi Lompo; Nagaonlé Éric Some; Adja Mariam Ouedraogo; Rodrigue P Yonli; Ousséini Diallo; Christian Napon; Athanase Millogo; Jean Kabore Journal: Med Trop Sante Int Date: 2021-11-11
Authors: Andreas Totzeck; Elakiya Ramakrishnan; Melina Schlag; Benjamin Stolte; Kathrin Kizina; Saskia Bolz; Andreas Thimm; Mark Stettner; Julian R Marchesi; Jan Buer; Christoph Kleinschnitz; Hedda Luise Verhasselt; Tim Hagenacker Journal: Ther Adv Neurol Disord Date: 2021-08-11 Impact factor: 6.570