| Literature DB >> 26035794 |
Biao Zheng1, Kenoki Ohuchida1, Lin Cui1, Ming Zhao1, Koji Shindo1, Kenji Fujiwara1, Tatsuya Manabe1, Nobuhiro Torata1, Taiki Moriyama1, Yoshihiro Miyasaka1, Takao Ohtsuka1, Shunichi Takahata1, Kazuhiro Mizumoto1, Yoshinao Oda2, Masao Tanaka1.
Abstract
The cell surface protein Transmembrane 4 L6 family member 1 (TM4SF1) has been detected in various tumors, and its expression on tumor cells is implicated in cancer cell metastasis and patient prognosis. The role of TM4SF1 in malignant tumors remains poorly understood, particularly in pancreatic cancer. We performed immunohistochemical staining to analyze the expression of TM4SF1 in resected pancreatic tissues and investigated the correlation between TM4SF1 expression and prognosis. The function of TM4SF1 in the invasion and migration of pancreatic cancer cells was analyzed in vitro using an RNA interference technique. In pancreatic cancer tissues, TM4SF1 expression was detected in cancer cells, and patients with high tumor levels of TM4SF1 showed longer survival times than those with low TM4SF1 levels (P=0.0332). In vitro, reduced TM4SF1 expression enhanced the migration (P<0.05) and invasion (P<0.05) of pancreatic cancer cells partially via decreased E-cadherin expression. TM4SF1 protein levels were also reduced after TGF-β1-induced epithelial-mesenchymal transition (EMT).TM4SF1 expression is associated with better prognosis in pancreatic cancer. Loss of TM4SF1 contributes to the invasion and migration of pancreatic cancer cells.Entities:
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Year: 2015 PMID： 26035794 DOI： 10.3892/ijo.2015.3022
Source DB: PubMed Journal: Int J Oncol ISSN： 1019-6439 Impact factor: 5.650