Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The anti-DNA antibody: origin and impact, dogmas and controversies.

Literature DB >> 26034836

The anti-DNA antibody: origin and impact, dogmas and controversies.

Abstract

The inclusion of 'the anti-DNA antibody' by the ACR and the Systemic Lupus International Collaborating Clinics (SLICC) as a criterion for systemic lupus erythematosus does not convey the diverse origins of these antibodies, whether their production is transient or persistent (which is heavily influenced by the nature of the inducing antigens), the specificities exerted by these antibodies or their clinical impact-or lack thereof. A substantial amount of data not considered in clinical medicine could be added from basic immunology evidence, which could change the paradigms linked to what 'the anti-DNA antibody' is, in a pathogenic, classification or diagnostic context.

Entities: Disease

Mesh：

Substances：
Autoantibodies
DNA

Year: 2015 PMID： 26034836 DOI： 10.1038/nrrheum.2015.69

Source DB: PubMed Journal: Nat Rev Rheumatol ISSN： 1759-4790 Impact factor: 20.543

118 in total

1. The serological activity of desoxypentosenucleic acids.

Authors: U BLIX; C N ILAND; M STACEY
Journal: Br J Exp Pathol Date: 1954-06

Review 2. Molecular Koch's postulates applied to bacterial pathogenicity--a personal recollection 15 years later.

Authors: Stanley Falkow
Journal: Nat Rev Microbiol Date: 2004-01 Impact factor: 60.633

Review 3. Chromatin higher-order structure and dynamics.

Authors: Christopher L Woodcock; Rajarshi P Ghosh
Journal: Cold Spring Harb Perspect Biol Date: 2010-04-07 Impact factor: 10.005

4. A viral DNA-binding domain elicits anti-DNA antibodies of different specificities.

Authors: María Laura Cerutti; Laura Mariana Zarebski; Gonzalo de Prat Gay; Fernando Alberto Goldbaum
Journal: Mol Immunol Date: 2005-02 Impact factor: 4.407

Review 5. Immunity and autoimmunity induced by polyomaviruses: clinical, experimental and theoretical aspects.

Authors: Ole Petter Rekvig; Signy Bendiksen; Ugo Moens
Journal: Adv Exp Med Biol Date: 2006 Impact factor: 2.622

6. Crystal structure of the nucleosome core particle at 2.8 A resolution.

Authors: K Luger; A W Mäder; R K Richmond; D F Sargent; T J Richmond
Journal: Nature Date: 1997-09-18 Impact factor: 49.962

Review 7. Regulatory and pathogenetic mechanisms of autoantibodies in SLE.

Authors: Marko Radic; Martin Herrmann; Johan van der Vlag; Ole Petter Rekvig
Journal: Autoimmunity Date: 2011-01-14 Impact factor: 2.815

8. Histone-specific Th0 and Th1 clones derived from systemic lupus erythematosus patients induce double-stranded DNA antibody production.

Authors: R E Voll; E A Roth; I Girkontaite; H Fehr; M Herrmann; H M Lorenz; J R Kalden
Journal: Arthritis Rheum Date: 1997-12

9. Correlation between the amino acid position of arginine in VH-CDR3 and specificity for native DNA among autoimmune antibodies.

Authors: M R Krishnan; N T Jou; T N Marion
Journal: J Immunol Date: 1996-09-15 Impact factor: 5.422

10. Autoantibody Profile of Egyptian Juvenile Systemic Lupus Erythematosus Patients and Its Association with Clinical Characteristics and Disease Activity.

Authors: Mohammed Abd El Monem Teama; Marwa Adham El-Mohamdy; Fatma Abdellah Abdullah Mahmoud; Fatma Mohammed Badr
Journal: Open Access Rheumatol Date: 2021-07-16

The anti-DNA antibody: origin and impact, dogmas and controversies.

1. The serological activity of desoxypentosenucleic acids.

Review 2. Molecular Koch's postulates applied to bacterial pathogenicity--a personal recollection 15 years later.

Review 3. Chromatin higher-order structure and dynamics.

4. A viral DNA-binding domain elicits anti-DNA antibodies of different specificities.

Review 5. Immunity and autoimmunity induced by polyomaviruses: clinical, experimental and theoretical aspects.

6. Crystal structure of the nucleosome core particle at 2.8 A resolution.

Review 7. Regulatory and pathogenetic mechanisms of autoantibodies in SLE.

8. Histone-specific Th0 and Th1 clones derived from systemic lupus erythematosus patients induce double-stranded DNA antibody production.

9. Correlation between the amino acid position of arginine in VH-CDR3 and specificity for native DNA among autoimmune antibodies.

10. T cell autoimmunity to histones and nucleosomes is a latent property of the normal immune system.

1. Anti-Smith antibody is associated with disease activity in patients with new-onset systemic lupus erythematosus.

Review 2. DNA as a self-antigen: nature and regulation.

Review 3. Evolving story of autoantibodies in systemic lupus erythematosus.

4. Precipitating anti-dsDNA peptide repertoires in lupus.

Review 5. Osteopontin in Immune-mediated Diseases.

Review 6. Anti-DNA antibodies--quintessential biomarkers of SLE.

Review 7. New insights into the role of antinuclear antibodies in systemic lupus erythematosus.

Review 8. Gut Microbiome and Metabolites in Systemic Lupus Erythematosus: Link, Mechanisms and Intervention.

Review 9. Update on Biologic Therapies for Systemic Lupus Erythematosus.

10. Autoantibody Profile of Egyptian Juvenile Systemic Lupus Erythematosus Patients and Its Association with Clinical Characteristics and Disease Activity.