Literature DB >> 26034205

The future of murine sepsis and trauma research models.

Philip A Efron1, Alicia M Mohr2, Frederick A Moore2, Lyle L Moldawer2.   

Abstract

Recent comparisons of the murine and human transcriptome in health and disease have called into question the appropriateness of the use of murine models for human sepsis and trauma research. More specifically, researchers have debated the suitability of mouse models of severe inflammation that is intended for eventual translation to human patients. This mini-review outlines this recent research, as well as specifically defines the arguments for and against murine models of sepsis and trauma research based on these transcriptional studies. In addition, we review newer advancements in murine models of infection and injury and define what we envision as an evolving but viable future for murine studies of sepsis and trauma. © Society for Leukocyte Biology.

Entities:  

Keywords:  immunity; translation

Mesh：

Year:  2015        PMID： 26034205      PMCID： PMC4661039          DOI： 10.1189/jlb.5MR0315-127R

Source DB:  PubMed          Journal:  J Leukoc Biol        ISSN： 0741-5400            Impact factor:   4.962


  63 in total

1.  Aged mice are unable to mount an effective myeloid response to sepsis.

Authors:  Dina C Nacionales; Lori F Gentile; Erin Vanzant; M Cecilia Lopez; Angela Cuenca; Alex G Cuenca; Ricardo Ungaro; Yi Li; Tezcan Ozrazgat Baslanti; Azra Bihorac; Frederick A Moore; Henry V Baker; Christiaan Leeuwenburgh; Lyle L Moldawer; Philip A Efron
Journal:  J Immunol       Date:  2013-12-13       Impact factor: 5.422

2.  Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures.

Authors:  Joseph Cuschieri; Jeffrey L Johnson; Jason Sperry; Michael A West; Ernest E Moore; Joseph P Minei; Paul E Bankey; Avery B Nathens; Alex G Cuenca; Philip A Efron; Laura Hennessy; Wenzhong Xiao; Michael N Mindrinos; Grace P McDonald-Smith; Philip H Mason; Timothy R Billiar; David A Schoenfeld; H Shaw Warren; J Perren Cobb; Lyle L Moldawer; Ronald W Davis; Ronald V Maier; Ronald G Tompkins
Journal:  Ann Surg       Date:  2012-05       Impact factor: 12.969

3.  A better understanding of why murine models of trauma do not recapitulate the human syndrome.

Authors:  Lori F Gentile; Dina C Nacionales; M Cecilia Lopez; Erin Vanzant; Angela Cuenca; Alex G Cuenca; Ricardo Ungaro; Tezcan Ozrazgat Baslanti; Bruce A McKinley; Azra Bihorac; Joseph Cuschieri; Ronald V Maier; Frederick A Moore; Christiaan Leeuwenburgh; Henry V Baker; Lyle L Moldawer; Philip A Efron
Journal:  Crit Care Med       Date:  2014-06       Impact factor: 7.598

Review 4.  Animal models in burn research.

Authors:  A Abdullahi; S Amini-Nik; M G Jeschke
Journal:  Cell Mol Life Sci       Date:  2014-04-09       Impact factor: 9.261

5.  Chronic restraint stress after injury and shock is associated with persistent anemia despite prolonged elevation in erythropoietin levels.

Authors:  Letitia E Bible; Latha V Pasupuleti; Amy V Gore; Ziad C Sifri; Kolenkode B Kannan; Alicia M Mohr
Journal:  J Trauma Acute Care Surg       Date:  2015-07       Impact factor: 3.313

Review 6.  Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care.

Authors:  Lori F Gentile; Alex G Cuenca; Philip A Efron; Darwin Ang; Azra Bihorac; Bruce A McKinley; Lyle L Moldawer; Frederick A Moore
Journal:  J Trauma Acute Care Surg       Date:  2012-06       Impact factor: 3.313

7.  Genomic responses in mouse models greatly mimic human inflammatory diseases.

Authors:  Keizo Takao; Tsuyoshi Miyakawa
Journal:  Proc Natl Acad Sci U S A       Date:  2014-08-04       Impact factor: 11.205

8.  Hemorrhage without tissue trauma produces immunosuppression and enhances susceptibility to sepsis.

Authors:  R N Stephan; T S Kupper; A S Geha; A E Baue; I H Chaudry
Journal:  Arch Surg       Date:  1987-01

9.  Sepsis and scientific revolutions.

Authors:  Andrew W Artenstein; Thomas L Higgins; Steven M Opal
Journal:  Crit Care Med       Date:  2013-12       Impact factor: 7.598

10.  MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis.

Authors:  Matthew J Delano; Philip O Scumpia; Jason S Weinstein; Dominique Coco; Srinivas Nagaraj; Kindra M Kelly-Scumpia; Kerri A O'Malley; James L Wynn; Svetlana Antonenko; Samer Z Al-Quran; Ryan Swan; Chun-Shiang Chung; Mark A Atkinson; Reuben Ramphal; Dmitry I Gabrilovich; Wesley H Reeves; Alfred Ayala; Joseph Phillips; Drake Laface; Paul G Heyworth; Michael Clare-Salzler; Lyle L Moldawer
Journal:  J Exp Med       Date:  2007-06-04       Impact factor: 14.307
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  54 in total

1.  The authors reply.

Authors:  Sarah A Sterling; Michael A Puskarich; Alan E Jones
Journal:  Crit Care Med       Date:  2016-10       Impact factor: 7.598

Review 2.  Murine Models of Sepsis and Trauma: Can We Bridge the Gap?

Authors:  Julie A Stortz; Steven L Raymond; Juan C Mira; Lyle L Moldawer; Alicia M Mohr; Philip A Efron
Journal:  ILAR J       Date:  2017-07-01

Review 3.  Current Murine Models of Sepsis.

Authors:  Anthony J Lewis; Christopher W Seymour; Matthew R Rosengart
Journal:  Surg Infect (Larchmt)       Date:  2016-06-15       Impact factor: 2.150

Review 4.  Clinical and Experimental Sepsis Impairs CD8 T-Cell-Mediated Immunity.

Authors:  Derek B Danahy; Robert K Strother; Vladimir P Badovinac; Thomas S Griffith
Journal:  Crit Rev Immunol       Date:  2016       Impact factor: 2.214

Review 5.  Sepsis-Induced T Cell Immunoparalysis: The Ins and Outs of Impaired T Cell Immunity.

Authors:  Isaac J Jensen; Frances V Sjaastad; Thomas S Griffith; Vladimir P Badovinac
Journal:  J Immunol       Date:  2018-03-01       Impact factor: 5.422

6.  Sex-based differences in the genomic response, innate immunity, organ dysfunction, and clinical outcomes after severe blunt traumatic injury and hemorrhagic shock.

Authors:  Maria-Cecilia Lopez; Philip A Efron; Tezcan Ozrazgat-Baslanti; Jianyi Zhang; Joseph Cuschieri; Ronald V Maier; Joseph P Minei; Henry V Baker; Frederick A Moore; Lyle L Moldawer; Scott C Brakenridge
Journal:  J Trauma Acute Care Surg       Date:  2016-09       Impact factor: 3.313

Review 7.  Could Biomarkers Direct Therapy for the Septic Patient?

Authors:  Clark R Sims; Trung C Nguyen; Philip R Mayeux
Journal:  J Pharmacol Exp Ther       Date:  2016-02-08       Impact factor: 4.030

Review 8.  Bench-to-Bedside: A Translational Perspective on Murine Models of Sepsis.

Authors:  Anthony J Lewis; Matthew R Rosengart
Journal:  Surg Infect (Larchmt)       Date:  2018-02-02       Impact factor: 2.150

9.  Patterns of gene expression among murine models of hemorrhagic shock/trauma and sepsis.

Authors:  Juan C Mira; Benjamin E Szpila; Dina C Nacionales; Maria-Cecilia Lopez; Lori F Gentile; Brittany J Mathias; Erin L Vanzant; Ricardo Ungaro; David Holden; Martin D Rosenthal; Jaimar Rincon; Patrick T Verdugo; Shawn D Larson; Frederick A Moore; Scott C Brakenridge; Alicia M Mohr; Henry V Baker; Lyle L Moldawer; Philip A Efron
Journal:  Physiol Genomics       Date:  2015-11-17       Impact factor: 3.107

Review 10.  An Immunological Perspective on Neonatal Sepsis.

Authors:  Bernard Kan; Hamid Reza Razzaghian; Pascal M Lavoie
Journal:  Trends Mol Med       Date:  2016-03-15       Impact factor: 11.951
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