Chao Zeng1, Jie Wei1, Hui Li1, Tuo Yang1, Fang-Jie Zhang1, Ding Pan1, Yong-Bing Xiao1, Tu-Bao Yang1, Guang-Hua Lei2. 1. From the Department of Orthopedics, Xiangya Hospital, and Department of Epidemiology and Health Statistics, School of Public Health Central South University, Central South University, Changsha, Hunan Province, China.C. Zeng, MD, Department of Orthopedics, Xiangya Hospital, Central South University; J. Wei, MD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; H. Li, MD; T. Yang, MD; F.J. Zhang, PhD; D. Pan, PhD; Y.B. Xiao, PhD, Department of Orthopedics, Xiangya Hospital, Central South University; T.B. Yang, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University. 2. From the Department of Orthopedics, Xiangya Hospital, and Department of Epidemiology and Health Statistics, School of Public Health Central South University, Central South University, Changsha, Hunan Province, China.C. Zeng, MD, Department of Orthopedics, Xiangya Hospital, Central South University; J. Wei, MD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; H. Li, MD; T. Yang, MD; F.J. Zhang, PhD; D. Pan, PhD; Y.B. Xiao, PhD, Department of Orthopedics, Xiangya Hospital, Central South University; T.B. Yang, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University. lgh9640@sina.cn.
Abstract
OBJECTIVE: To establish whether there is a relationship between serum magnesium (Mg) concentration and radiographic knee osteoarthritis (OA). METHODS: There were 2855 subjects in this cross-sectional study. Serum Mg concentration was measured using the chemiluminescence method. Radiographic OA of the knee was defined as changes consistent with Kellgren-Lawrence (K-L) grade 2 on at least 1 side. Mg concentration was classified into 1 of 4 quartiles: ≤ 0.87, 0.88-0.91, 0.92-0.96, or ≥ 0.97 mmol/l. Multivariable logistic analysis was used to test the association between serum Mg and radiographic knee OA after adjustment for potentially confounding factors. The OR with 95% CI for the association between radiographic knee OA and serum Mg concentration were calculated for each quartile. The quartile with the lowest value was regarded as the reference category. RESULTS: Significant association between serum Mg concentration and radiographic knee OA was observed in the model after adjustment for age, sex, and body mass index, as well as in the multivariable model. The multivariable-adjusted OR (95% CI) for radiographic knee OA in the second, third, and fourth serum Mg concentration quartiles were 0.90 (95% CI 0.71-1.13), 0.92 (95% CI 0.73-1.16), and 0.72 (95% CI 0.57-0.92), respectively, compared with the lowest (first) quartile. A clear trend (p for trend was 0.01) was observed. The relative odds of radiographic knee OA was decreased by 0.72 times in the fourth serum Mg quartile compared with the lowest quartile. CONCLUSION: Serum Mg concentration may have an inverse relationship with radiographic OA of the knee.
OBJECTIVE: To establish whether there is a relationship between serum magnesium (Mg) concentration and radiographic knee osteoarthritis (OA). METHODS: There were 2855 subjects in this cross-sectional study. Serum Mg concentration was measured using the chemiluminescence method. Radiographic OA of the knee was defined as changes consistent with Kellgren-Lawrence (K-L) grade 2 on at least 1 side. Mg concentration was classified into 1 of 4 quartiles: ≤ 0.87, 0.88-0.91, 0.92-0.96, or ≥ 0.97 mmol/l. Multivariable logistic analysis was used to test the association between serum Mg and radiographic knee OA after adjustment for potentially confounding factors. The OR with 95% CI for the association between radiographic knee OA and serum Mg concentration were calculated for each quartile. The quartile with the lowest value was regarded as the reference category. RESULTS: Significant association between serum Mg concentration and radiographic knee OA was observed in the model after adjustment for age, sex, and body mass index, as well as in the multivariable model. The multivariable-adjusted OR (95% CI) for radiographic knee OA in the second, third, and fourth serum Mg concentration quartiles were 0.90 (95% CI 0.71-1.13), 0.92 (95% CI 0.73-1.16), and 0.72 (95% CI 0.57-0.92), respectively, compared with the lowest (first) quartile. A clear trend (p for trend was 0.01) was observed. The relative odds of radiographic knee OA was decreased by 0.72 times in the fourth serum Mg quartile compared with the lowest quartile. CONCLUSION: Serum Mg concentration may have an inverse relationship with radiographic OA of the knee.
Authors: Tuo Yang; Yi Zhang; Jie Wei; Chao Zeng; Liang-Jun Li; Xi Xie; Yi-Lun Wang; Dong-Xing Xie; Hui Li; Cui Yang; Guang-Hua Lei Journal: Rheumatol Int Date: 2016-10-04 Impact factor: 2.631
Authors: C Zeng; T Neogi; A T Chan; J Wei; D Misra; N Lu; H K Choi; G Lei; Y Zhang Journal: Osteoarthritis Cartilage Date: 2022-01-11 Impact factor: 6.576
Authors: Ruijun Bai; Michael Z Miao; Hui Li; Yiqing Wang; Ruixue Hou; Ke He; Xuan Wu; Hongyu Jin; Chao Zeng; Yang Cui; Guanghua Lei Journal: Arthritis Res Ther Date: 2022-07-08 Impact factor: 5.606
Authors: Yi Zhang; Chao Zeng; Jie Wei; Hui Li; Tuo Yang; Ye Yang; Zhen-han Deng; Xiang Ding; Guanghua Lei Journal: BMJ Open Date: 2016-03-11 Impact factor: 2.692