Literature DB >> 26033933

Substantial Differentiation of Human Neural Stem Cells Into Motor Neurons on a Biomimetic Polyurea.

Donghwa Yun1, Young M Lee2, Melissa R Laughter1, Curt R Freed2, Daewon Park3.   

Abstract

To find the first restorative treatment for spinal cord injury (SCI), researchers have focused on stem cell therapies. However, one obstacle is the lack of an implantable cell scaffold that can support efficient motor neuron (MN) differentiation and proliferation. We aimed to overcome this through the use of an RGD functionalized novel biomimetic polyurea, optimized to encourage efficient differentiation of MNs. Images taken after 14-days showed increased differentiation (∼40%) of hNSCs into MNs as well as increased cell count on the biomimetic polymer compared to PDL-Laminin coating, indicating that the RGD-polyurea provides a favorable microenvironment for hNSC survival, having promising implications for future SCI therapies.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  biomaterials; biomimetic polymer; motor neuron; neural stem cells; spinal cord injury

Mesh：

Substances：

Year:  2015        PMID： 26033933      PMCID： PMC4558270          DOI： 10.1002/mabi.201500066

Source DB:  PubMed          Journal:  Macromol Biosci        ISSN： 1616-5187            Impact factor:   4.979


  13 in total

Review 1.  Apoptosis-an introduction.

Authors:  Alfons Lawen
Journal:  Bioessays       Date:  2003-09       Impact factor: 4.345

2.  Neural stem cell adhesion and proliferation on phospholipid bilayers functionalized with RGD peptides.

Authors:  Badriprasad Ananthanarayanan; Lauren Little; David V Schaffer; Kevin E Healy; Matthew Tirrell
Journal:  Biomaterials       Date:  2010-08-21       Impact factor: 12.479

3.  Regulation of neural progenitor proliferation and survival by beta1 integrins.

Authors:  Dino P Leone; João B Relvas; Lia S Campos; Silvio Hemmi; Cord Brakebusch; Reinhard Fässler; Charles Ffrench-Constant; Ueli Suter
Journal:  J Cell Sci       Date:  2005-05-31       Impact factor: 5.285

4.  Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes.

Authors:  Mark E Hester; Matthew J Murtha; SungWon Song; Meghan Rao; Carlos J Miranda; Kathrin Meyer; Jinbin Tian; Gabriella Boulting; David V Schaffer; Michael X Zhu; Samuel L Pfaff; Fred H Gage; Brian K Kaspar
Journal:  Mol Ther       Date:  2011-07-19       Impact factor: 11.454

5.  Biomimetic interfacial interpenetrating polymer networks control neural stem cell behavior.

Authors:  Krishanu Saha; Elizabeth F Irwin; Julia Kozhukh; David V Schaffer; Kevin E Healy
Journal:  J Biomed Mater Res A       Date:  2007-04       Impact factor: 4.396

Review 6.  Designing materials to direct stem-cell fate.

Authors:  Matthias P Lutolf; Penney M Gilbert; Helen M Blau
Journal:  Nature       Date:  2009-11-26       Impact factor: 49.962

7.  Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation.

Authors:  Francesco Paolo Di Giorgio; Gabriella L Boulting; Samuel Bobrowicz; Kevin C Eggan
Journal:  Cell Stem Cell       Date:  2008-12-04       Impact factor: 24.633

8.  Directed differentiation of human-induced pluripotent stem cells generates active motor neurons.

Authors:  Saravanan Karumbayaram; Bennett G Novitch; Michaela Patterson; Joy A Umbach; Laura Richter; Anne Lindgren; Anne E Conway; Amander T Clark; Steve A Goldman; Kathrin Plath; Martina Wiedau-Pazos; Harley I Kornblum; William E Lowry
Journal:  Stem Cells       Date:  2009-04       Impact factor: 6.277

9.  Functional enhancement of neuronal cell behaviors and differentiation by elastin-mimetic recombinant protein presenting Arg-Gly-Asp peptides.

Authors:  Won Bae Jeon; Bo Hyung Park; Seong Kyoon Choi; Kyeong-Min Lee; Jin-Kyu Park
Journal:  BMC Biotechnol       Date:  2012-09-14       Impact factor: 2.563

10.  Axonal transport of class II and III beta-tubulin: evidence that the slow component wave represents the movement of only a small fraction of the tubulin in mature motor axons.

Authors:  P N Hoffman; M A Lopata; D F Watson; R F Luduena
Journal:  J Cell Biol       Date:  1992-11       Impact factor: 10.539
View more
  6 in total

1.  A Self-Assembling Injectable Biomimetic Microenvironment Encourages Retinal Ganglion Cell Axon Extension in Vitro.

Authors:  Melissa R Laughter; David A Ammar; James R Bardill; Brisa Pena; Malik Y Kahook; David J Lee; Daewon Park
Journal:  ACS Appl Mater Interfaces       Date:  2016-08-02       Impact factor: 9.229

2.  Injectable Neurotrophic Factor Delivery System Supporting Retinal Ganglion Cell Survival and Regeneration Following Optic Nerve Crush.

Authors:  Melissa R Laughter; James R Bardill; David A Ammar; Brisa Pena; David J Calkins; Daewon Park
Journal:  ACS Biomater Sci Eng       Date:  2018-07-23

3.  Engineered Biomimetic Neural Stem Cell Niche.

Authors:  Rita Matta; Anjelica L Gonzalez
Journal:  Curr Stem Cell Rep       Date:  2019-05-20

4.  Injectable Carbon Nanotube-Functionalized Reverse Thermal Gel Promotes Cardiomyocytes Survival and Maturation.

Authors:  Brisa Peña; Susanna Bosi; Brian A Aguado; Daniele Borin; Nikki L Farnsworth; Evgenia Dobrinskikh; Teisha J Rowland; Valentina Martinelli; Mark Jeong; Matthew R G Taylor; Carlin S Long; Robin Shandas; Orfeo Sbaizero; Maurizio Prato; Kristi S Anseth; Daewon Park; Luisa Mestroni
Journal:  ACS Appl Mater Interfaces       Date:  2017-09-12       Impact factor: 9.229

5.  A nerve guidance conduit with topographical and biochemical cues: potential application using human neural stem cells.

Authors:  Phillip M Jenkins; Melissa R Laughter; David J Lee; Young M Lee; Curt R Freed; Daewon Park
Journal:  Nanoscale Res Lett       Date:  2015-06-12       Impact factor: 4.703

6.  An injectable sulfonated reversible thermal gel for therapeutic angiogenesis to protect cardiac function after a myocardial infarction.

Authors:  David J Lee; Maria A Cavasin; Adam J Rocker; Danielle E Soranno; Xianzhong Meng; Robin Shandas; Daewon Park
Journal:  J Biol Eng       Date:  2019-01-17       Impact factor: 4.355
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.