Literature DB >> 26033925

Dexamethasone-Conjugated Polyamidoamine Dendrimer for Delivery of the Heme Oxygenase-1 Gene into the Ischemic Brain.

Pureum Jeon1, Manbok Choi1, Jungju Oh1, Minhyung Lee2.   

Abstract

Heme oxygenase-1 (HO-1) has anti-apoptotic and anti-inflammatory effects. In this study, the HO-1 gene was delivered into the brain using dexamethasone-conjugated polyamidoamine generation 2 (PAMAM G2-Dexa) for the treatment of ischemic stroke. PAMAM G2-Dexa formed stable complexes with plasmid DNA (pDNA). The pDNA delivery efficiency of PAMAM G2-Dexa was higher than that of polyethylenimine (PEI25k, 25 kDa), dexamethasone-conjugated PEI (PEI-Dexa), and PAMAM G2 in Neuro2A cells. Therapeutic effect of PAMAM G2-Dexa/pHO-1 complexes was evaluated in a stroke animal model. PAMAM G2-Dexa delivered pHO-1 more efficiently into the ischemic brain than PEI25k and PEI-Dexa with higher therapeutic effect. Therefore, PAMAM G2-Dexa/pHO-1 complexes may be useful for ischemic stroke gene therapy.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  dexamethasone; gene therapy; heme oxygenase-1; polyamidoamine; stroke

Mesh：

Substances：

Year:  2015        PMID： 26033925     DOI： 10.1002/mabi.201500058

Source DB:  PubMed          Journal:  Macromol Biosci        ISSN： 1616-5187            Impact factor:   4.979


  6 in total

1.  Delivery of Hypoxia-Inducible Heme Oxygenase-1 Gene for Site-Specific Gene Therapy in the Ischemic Stroke Animal Model.

Authors:  Manbok Choi; Jungju Oh; Taiyoun Rhim; Minhyung Lee
Journal:  Pharm Res       Date:  2016-06-20       Impact factor: 4.200

Review 2.  Nanoparticles in the diagnosis and treatment of vascular aging and related diseases.

Authors:  Hui Xu; Shuang Li; You-Shuo Liu
Journal:  Signal Transduct Target Ther       Date:  2022-07-11

Review 3.  Neurovascular glucocorticoid receptors and glucocorticoids: implications in health, neurological disorders and drug therapy.

Authors:  Sherice Williams; Chaitali Ghosh
Journal:  Drug Discov Today       Date:  2019-09-18       Impact factor: 7.851

Review 4.  Nanocarriers for Stroke Therapy: Advances and Obstacles in Translating Animal Studies.

Authors:  Syed Abdullah Alkaff; Krishna Radhakrishnan; Anu Maashaa Nedumaran; Ping Liao; Bertrand Czarny
Journal:  Int J Nanomedicine       Date:  2020-01-21

Review 5.  Recent advances in the development of nanomedicines for the treatment of ischemic stroke.

Authors:  Xing Tian; Taojian Fan; Wentian Zhao; Ghulam Abbas; Bo Han; Ke Zhang; Nan Li; Ning Liu; Weiyuan Liang; Hao Huang; Wen Chen; Bing Wang; Zhongjian Xie
Journal:  Bioact Mater       Date:  2021-02-20

Review 6.  Dexamethasone Conjugates: Synthetic Approaches and Medical Prospects.

Authors:  Natallia V Dubashynskaya; Anton N Bokatyi; Yury A Skorik
Journal:  Biomedicines       Date:  2021-03-27
  6 in total

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