OBJECTIVES: To assess the difference in hyperlipidemia between patients with bicuspid aortic valve (BAV) and those with a normal aortic valve (NAV), and to compare aortic valve stenosis (AS), with aortic valve regurgitation (AR). METHODS: Among 32 patients with BAV and 142 patients with NAV who underwent aortic valve replacement, 81 patients had AR and 91 patients had AS. The preoperative clinical characteristics were compared between the BAV and NAV patients. Patients with replacement of the ascending aorta were included, and those who underwent combined valvular surgery, coronary artery bypass grafting, or statin treatment were excluded. RESULTS: The proportions of females patients (p = 0.42), patients with diabetes (p = 0.26) and patients on dialysis (p = 0.69) were similar in the two groups. Mean age was significantly lower, the mean diameter of the ascending aorta was significantly larger, and the rate of surgical intervention for the ascending aorta was significantly higher in the BAV group than in the NAV group (all p < 0.0001). The mean levels of low-density lipoprotein cholesterol (LDL) (p < 0.0001) and total cholesterol (TC) (p = 0.0003) were significantly higher in the BAV group than in the NAV group, in the analysis of only patients with AS, whereas these levels did not differ significantly between the groups, when only patients with AR were considered. CONCLUSION: BAV with AS is associated with hypercholesterolemia. However, BAV with AR was not associated with hypercholesterolemia.
OBJECTIVES: To assess the difference in hyperlipidemia between patients with bicuspid aortic valve (BAV) and those with a normal aortic valve (NAV), and to compare aortic valve stenosis (AS), with aortic valve regurgitation (AR). METHODS: Among 32 patients with BAV and 142 patients with NAV who underwent aortic valve replacement, 81 patients had AR and 91 patients had AS. The preoperative clinical characteristics were compared between the BAV and NAVpatients. Patients with replacement of the ascending aorta were included, and those who underwent combined valvular surgery, coronary artery bypass grafting, or statin treatment were excluded. RESULTS: The proportions of females patients (p = 0.42), patients with diabetes (p = 0.26) and patients on dialysis (p = 0.69) were similar in the two groups. Mean age was significantly lower, the mean diameter of the ascending aorta was significantly larger, and the rate of surgical intervention for the ascending aorta was significantly higher in the BAV group than in the NAV group (all p < 0.0001). The mean levels of low-density lipoprotein cholesterol (LDL) (p < 0.0001) and total cholesterol (TC) (p = 0.0003) were significantly higher in the BAV group than in the NAV group, in the analysis of only patients with AS, whereas these levels did not differ significantly between the groups, when only patients with AR were considered. CONCLUSION: BAV with AS is associated with hypercholesterolemia. However, BAV with AR was not associated with hypercholesterolemia.
Authors: Hector I Michelena; Amber D Khanna; Douglas Mahoney; Edit Margaryan; Yan Topilsky; Rakesh M Suri; Ben Eidem; William D Edwards; Thoralf M Sundt; Maurice Enriquez-Sarano Journal: JAMA Date: 2011-09-14 Impact factor: 56.272
Authors: Sachin S Goel; E Murat Tuzcu; Shikhar Agarwal; Olcay Aksoy; Amar Krishnaswamy; Brian P Griffin; Lars G Svensson; Samir R Kapadia Journal: Am J Cardiol Date: 2011-11-15 Impact factor: 2.778
Authors: Jacob Gutierrez; Brett A Davis; Kimberly A Nevonen; Samantha Ward; Lucia Carbone; Cheryl L Maslen Journal: Front Genet Date: 2022-05-31 Impact factor: 4.772
Authors: Burak Acar; Cagrı Yayla; Murat Gul; Mustafa Karanfil; Sefa Unal; Fatih Uçar; Serdar Mevlut Kuyumcu; Ahmet Goktug Ertem; Yasin Ozen; Mustafa Bilal Ozbay; Ozcan Ozeke; Sinan Aydogdu Journal: Afr Health Sci Date: 2021-03 Impact factor: 0.927