Tae-Bin Won1, Kyu Young Choi2, Chae-Seo Rhee3, Hong-Ryul Jin4, Jong Sook Yi5, Hun-Jong Dhong6, Sung Won Kim7, Ji Ho Choi8, Jin Kook Kim9, Young-Jun Chung10, Yong-Min Kim11, Sang-Wook Kim12, Jung Soo Kim13, Sam Hyun Kwon14, Sang-Chul Lim15, Hwan-Jung Roh16. 1. Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea. 2. Department of Otorhinolaryngology-Head and Neck Surgery, Kangnam Sacred Heart Hospital, Seoul, Korea. 3. Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, Korea. 4. Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Boramae Medical Center, Seoul, Korea. 5. Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, Seoul, Korea. 6. Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Seoul, Korea. 7. Department of Otorhinolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, Seoul, Korea. 8. Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Ansan Hospital, Ansan, Korea. 9. Department of Otorhinolaryngology-Head and Neck Surgery, Konkuk University Hospital, Seoul, Korea. 10. Department of Otorhinolaryngology-Head and Neck Surgery, Dankook University Hospital, Cheonan, Korea. 11. Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University Hospital, Daejeon, Korea. 12. Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, Korea. 13. Department of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University Hospital, Daegu, Korea. 14. Department of Otorhinolaryngology-Head and Neck Surgery, Chonbuk National University Hospital, Jeonju, Korea. 15. Department of Otorhinolaryngology-Head and Neck Surgery, Chonnam National University Hwasun Hospital, Gwangju, Korea. 16. Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University Yangsan Hospital, Yangsan, Korea.
Abstract
BACKGROUND: The aim of this work was to evaluate factors that influence local recurrence and survival after surgical resection of sinonasal malignant melanoma, using a large population-based multicenter study in Korea. METHODS: Retrospective analysis was performed for 155 newly diagnosed sinonasal malignant melanoma patients gathered from 15 university hospitals throughout Korea. Demographic data, tumor characteristics, surgical approach, adjuvant treatment, recurrence, and outcomes were analyzed. RESULTS: Three-year and 5-year overall survival rates were 48.8% and 40.1%, respectively. Local recurrence rate was 46.6%, with a mean recurrence time of 15.5 months. On multivariate analysis, patients who underwent surgery that included an endoscopic approach showed decreased local recurrence rate (p = 0.042) and increased survival rate (hazard ratio [HR], 1.702; 95% confidence interval [CI], 1.007 to 2.875; p = 0.047) compared to those who underwent an external approach. Patients with postoperative radiotherapy showed a decreased local recurrence rate (p = 0.001), but without impact on survival rate. Male gender, tumor beyond the nasal cavity, and presence of distant metastasis were associated with poor survival. CONCLUSION: An endoscopic-including surgical approach was associated with improved local control and survival in sinonasal malignant melanoma patients. Postoperative radiotherapy helped increase the local control rate.
BACKGROUND: The aim of this work was to evaluate factors that influence local recurrence and survival after surgical resection of sinonasal malignant melanoma, using a large population-based multicenter study in Korea. METHODS: Retrospective analysis was performed for 155 newly diagnosed sinonasal malignant melanomapatients gathered from 15 university hospitals throughout Korea. Demographic data, tumor characteristics, surgical approach, adjuvant treatment, recurrence, and outcomes were analyzed. RESULTS: Three-year and 5-year overall survival rates were 48.8% and 40.1%, respectively. Local recurrence rate was 46.6%, with a mean recurrence time of 15.5 months. On multivariate analysis, patients who underwent surgery that included an endoscopic approach showed decreased local recurrence rate (p = 0.042) and increased survival rate (hazard ratio [HR], 1.702; 95% confidence interval [CI], 1.007 to 2.875; p = 0.047) compared to those who underwent an external approach. Patients with postoperative radiotherapy showed a decreased local recurrence rate (p = 0.001), but without impact on survival rate. Male gender, tumor beyond the nasal cavity, and presence of distant metastasis were associated with poor survival. CONCLUSION: An endoscopic-including surgical approach was associated with improved local control and survival in sinonasal malignant melanomapatients. Postoperative radiotherapy helped increase the local control rate.
Authors: Tiffany N Chao; Edward C Kuan; Charles C L Tong; Michael A Kohanski; M Sean Grady; James N Palmer; Nithin D Adappa; Bert W O'Malley Journal: J Neurol Surg B Skull Base Date: 2020-02-07
Authors: Alexandros Andrianakis; Peter Kiss; Markus Pomberger; Axel Wolf; Dietmar Thurnher; Peter Valentin Tomazic Journal: Wien Klin Wochenschr Date: 2021-04-12 Impact factor: 1.704