Benjamin Gupta1, Norman Stanton2, Hedley Coleman3, Chris White4, Jasvir Singh2. 1. Department of Oral and Maxillofacial Surgery, Prince of Wales Hospital, Randwick, NSW, Australia. Electronic address: bengupta@gmail.com. 2. Department of Oral and Maxillofacial Surgery, Prince of Wales Hospital, Randwick, NSW, Australia. 3. Department of Tissue Pathology and Diagnostic Oncology, Pathology West and the University of Sydney Westmead Hospital, Westmead, NSW, Australia. 4. Department of Endocrinology, Prince of Wales Hospital, Randwick, NSW, Australia.
Abstract
PURPOSE: To describe the efficacy of denosumab in the treatment of an aggressive giant cell granuloma of the mandible. METHODS: Denosumab was administered to a patient with a large aggressive giant cell granuloma of the mandible resistant to standard medical therapy. The effectiveness and response was measured on the basis of patient symptoms and radiological parameters. RESULTS: A significant reduction in patient symptoms was reported in association with tumour regression on follow up radiographs. CONCLUSION: This report demonstrates potential use of denosumab in aggressive giant cell granulomas of the jaws that have been resistant to medical therapy. Crown
PURPOSE: To describe the efficacy of denosumab in the treatment of an aggressive giant cell granuloma of the mandible. METHODS:Denosumab was administered to a patient with a large aggressive giant cell granuloma of the mandible resistant to standard medical therapy. The effectiveness and response was measured on the basis of patient symptoms and radiological parameters. RESULTS: A significant reduction in patient symptoms was reported in association with tumour regression on follow up radiographs. CONCLUSION: This report demonstrates potential use of denosumab in aggressive giant cell granulomas of the jaws that have been resistant to medical therapy. Crown
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