Literature DB >> 26032473

Highly Efficient Glutathione Peroxidase and Peroxiredoxin Mimetics Protect Mammalian Cells against Oxidative Damage.

Debasish Bhowmick1, Shubhi Srivastava2, Patrick D'Silva3, Govindasamy Mugesh4.   

Abstract

Novel isoselenazoles with high glutathione peroxidase (GPx) and peroxiredoxin (Prx) activities provide remarkable cytoprotection to human cells, mainly by exhibiting antioxidant activities in the presence of cellular thiols. The cytotoxicity of the isoselenazoles is found to be significantly lower than that of ebselen, which is being clinically evaluated by several groups for the treatment of reperfusion injuries and stroke, hearing loss, and bipolar disorder. The compounds reported in this paper have the potential to be used as therapeutic agents for disorders mediated by reactive oxygen species.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  DNA damage; antioxidants; glutathione peroxidase; reactive oxygen species; selenium

Mesh：

Substances：

Year:  2015        PMID： 26032473     DOI： 10.1002/anie.201502430

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  8 in total

1.  Alkyl chain modulated cytotoxicity and antioxidant activity of bioinspired amphiphilic selenolanes.

Authors:  Prachi Verma; Amit Kunwar; Kenta Arai; Michio Iwaoka; K Indira Priyadarsini
Journal:  Toxicol Res (Camb)       Date:  2015-11-25       Impact factor: 3.524

2.  Development of ebsulfur analogues as potent antibacterials against methicillin-resistant Staphylococcus aureus.

Authors:  Huy X Ngo; Sanjib K Shrestha; Keith D Green; Sylvie Garneau-Tsodikova
Journal:  Bioorg Med Chem       Date:  2016-03-31       Impact factor: 3.641

3.  Selenium- and Tellurium-Based Antioxidants for Modulating Inflammation and Effects on Osteoblastic Activity.

Authors:  Xi Lu; Gemma Mestres; Vijay Pal Singh; Pedram Effati; Jia-Fei Poon; Lars Engman; Marjam Karlsson Ott
Journal:  Antioxidants (Basel)       Date:  2017-02-14

4.  Glutathione Peroxidase-Like Activity of Amino-Substituted Water-Soluble Cyclic Selenides: A Shift of the Major Catalytic Cycle in Methanol.

Authors:  Kenta Arai; Ayako Tashiro; Yuui Osaka; Michio Iwaoka
Journal:  Molecules       Date:  2017-02-25       Impact factor: 4.411

Review 5.  Adaptive responses of sterically confined intramolecular chalcogen bonds.

Authors:  Karuthapandi Selvakumar; Harkesh B Singh
Journal:  Chem Sci       Date:  2018-07-25       Impact factor: 9.825

6.  A selenium-catalysed para-amination of phenols.

Authors:  Dingyuan Yan; Guoqiang Wang; Feng Xiong; Wei-Yin Sun; Zhuangzhi Shi; Yi Lu; Shuhua Li; Jing Zhao
Journal:  Nat Commun       Date:  2018-10-16       Impact factor: 14.919

7.  The effect of cold atmospheric plasma on diabetes-induced enzyme glycation, oxidative stress, and inflammation; in vitro and in vivo.

Authors:  Alireza Rezaeinezhad; Pegah Eslami; Hossein Mirmiranpour; Hamid Ghomi
Journal:  Sci Rep       Date:  2019-12-27       Impact factor: 4.379

8.  Multifunctional carbonized nanogels to treat lethal acute hepatopancreatic necrosis disease.

Authors:  Shao-Chieh Yen; Ju-Yi Mao; Hung-Yun Lin; Huai-Ting Huang; Scott G Harroun; Amit Nain; Huan-Tsung Chang; Han-You Lin; Li-Li Chen; Chih-Ching Huang; Han-Jia Lin
Journal:  J Nanobiotechnology       Date:  2021-12-24       Impact factor: 10.435
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.