Jesús Aibar1, Mario Martínez-Florensa2, Pedro Castro3, Esther Carrasco4, Cristina Escoda-Ferran5, Sara Fernández6, Montserrat Butjosa7, Cristina Hernández8, Mariano Rinaudo9, Francisco Lozano10, Josep Maria Nicolás11. 1. Medical Intensive Care Unit, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. Electronic address: jaibar@clinic.ub.es. 2. Group of Immunoreceptors of the Innate and Adaptive System, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Villarroel 170, 08036 Barcelona, Spain. Electronic address: mariomartnez80@gmail.com. 3. Medical Intensive Care Unit, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. Electronic address: pcastro@clinic.ub.es. 4. Group of Immunoreceptors of the Innate and Adaptive System, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Villarroel 170, 08036 Barcelona, Spain. Electronic address: esthercdm@gmail.com. 5. Group of Immunoreceptors of the Innate and Adaptive System, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Villarroel 170, 08036 Barcelona, Spain. Electronic address: crisescodaiferran@gmail.com. 6. Medical Intensive Care Unit, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. Electronic address: sfernanm@clinic.ub.es. 7. Medical Intensive Care Unit, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. Electronic address: mbutjosa@clinic.ub.es. 8. Medical Intensive Care Unit, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. Electronic address: chernan1@clinic.ub.es. 9. Medical Intensive Care Unit, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. Electronic address: marianorinaudo@gmail.com. 10. Group of Immunoreceptors of the Innate and Adaptive System, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Villarroel 170, 08036 Barcelona, Spain; Department of Immunology, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona Villarroel 170, 08036 Barcelona, Spain. Electronic address: flozano@clinic.ub.es. 11. Medical Intensive Care Unit, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. Electronic address: nicolas@clinic.ub.es.
Abstract
PURPOSE: Soluble forms of CD5 and CD6 lymphocyte surface receptors (sCD5 and sCD6) are molecules that seem to prevent experimental sepsis when exogenously administered. The aim of this study was to assess sCD5 and sCD6 levels in patients with septic syndromes. MATERIALS AND METHODS: The study population consisted of 218 patients admitted to the medical intensive care unit (ICU) presenting either septic syndromes or noninfectious systemic inflammatory response syndrome at admission or within the first 48 hours. The sCD5 and sCD6 levels were analyzed by sandwich enzyme-linked immunosorbent assay. RESULTS: Almost 50% of the patients had undetectable levels of sCD5 or sCD6, with no differences in clinical or biological variables with detectable patients. There was a correlation between the delta Sequential Organ Failure Assessment score and both sCD6 and sCD5 levels in all groups. Patients with sCD5 or sCD6 levels greater than 1500 ng/mL presented a higher in-ICU mortality (P < .05). Logistic regression analysis showed that increased sCD6 levels were associated with an increased risk of in-ICU mortality. CONCLUSIONS: Levels of sCD5 and sCD6 in critically ill patients with systemic inflammatory response syndrome present a high variation and an elevated proportion of undetectability. Levels of sCD6 are associated with an increased risk of mortality in these patients.
PURPOSE: Soluble forms of CD5 and CD6 lymphocyte surface receptors (sCD5 and sCD6) are molecules that seem to prevent experimental sepsis when exogenously administered. The aim of this study was to assess sCD5 and sCD6 levels in patients with septic syndromes. MATERIALS AND METHODS: The study population consisted of 218 patients admitted to the medical intensive care unit (ICU) presenting either septic syndromes or noninfectious systemic inflammatory response syndrome at admission or within the first 48 hours. The sCD5 and sCD6 levels were analyzed by sandwich enzyme-linked immunosorbent assay. RESULTS: Almost 50% of the patients had undetectable levels of sCD5 or sCD6, with no differences in clinical or biological variables with detectable patients. There was a correlation between the delta Sequential Organ Failure Assessment score and both sCD6 and sCD5 levels in all groups. Patients with sCD5 or sCD6 levels greater than 1500 ng/mL presented a higher in-ICU mortality (P < .05). Logistic regression analysis showed that increased sCD6 levels were associated with an increased risk of in-ICU mortality. CONCLUSIONS: Levels of sCD5 and sCD6 in critically illpatients with systemic inflammatory response syndrome present a high variation and an elevated proportion of undetectability. Levels of sCD6 are associated with an increased risk of mortality in these patients.
Authors: Jose Manuel Sánchez-Maldonado; Rafael Cáliz; Miguel Ángel López-Nevot; Antonio José Cabrera-Serrano; Ana Moñiz-Díez; Helena Canhão; Rob Ter Horst; Luca Quartuccio; Signe B Sorensen; Bente Glintborg; Merete L Hetland; Ileana Filipescu; Eva Pérez-Pampin; Pablo Conesa-Zamora; Jerzy Swierkot; Alfons A den Broeder; Salvatore De Vita; Eva Rabing Brix Petersen; Yang Li; Miguel A Ferrer; Alejandro Escudero; Mihai G Netea; Marieke J H Coenen; Vibeke Andersen; João E Fonseca; Manuel Jurado; Katarzyna Bogunia-Kubik; Eduardo Collantes; Juan Sainz Journal: Front Immunol Date: 2021-10-27 Impact factor: 7.561