Literature DB >> 26031462

Predicting Pediatric Drug Disposition-Present and Future Directions of Pediatric Physiologically-Based Pharmacokinetics.

Shogo John Miyagi, Janel R Long-Boyle1.   

Abstract

This mini-review examines the current state of pediatric physiologically-based pharmacokinetic (PBPK) modeling, including methodologies, approaches, and recent developments. Also discussed are United States regulations that have helped to shape the pediatric PBPK landscape and the ongoing urgent need for pediatric clinical studies. Finally, current pediatric PBPK software as well as the areas of focus for future studies will be reviewed.

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Year:  2015        PMID: 26031462     DOI: 10.2174/1872312809666150602151429

Source DB:  PubMed          Journal:  Drug Metab Lett        ISSN: 1872-3128


  4 in total

Review 1.  State-of-the-Art Review on Physiologically Based Pharmacokinetic Modeling in Pediatric Drug Development.

Authors:  Venkata Yellepeddi; Joseph Rower; Xiaoxi Liu; Shaun Kumar; Jahidur Rashid; Catherine M T Sherwin
Journal:  Clin Pharmacokinet       Date:  2019-01       Impact factor: 6.447

2.  The Ontogeny and Population Variability of Human Hepatic NADPH Dehydrogenase Quinone Oxido-Reductase 1 (NQO1).

Authors:  Luc R A Rougée; Zoe Riches; Jacob M Berman; Abby C Collier
Journal:  Drug Metab Dispos       Date:  2016-02-08       Impact factor: 3.922

3.  Age-Related Changes in Pediatric Physiology: Quantitative Analysis of Organ Weights and Blood Flows : Age-Related Changes in Pediatric Physiology.

Authors:  Hsuan Ping Chang; Se Jin Kim; Di Wu; Kushal Shah; Dhaval K Shah
Journal:  AAPS J       Date:  2021-03-31       Impact factor: 4.009

Review 4.  Developmental regulation of kidney and liver solute carrier and ATP-binding cassette drug transporters and drug metabolizing enzymes: the role of remote organ communication.

Authors:  Jeremiah D Momper; Sanjay K Nigam
Journal:  Expert Opin Drug Metab Toxicol       Date:  2018-06-04       Impact factor: 4.481

  4 in total

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