Literature DB >> 26029832

Elafin in pulmonary arterial hypertension. Beyond targeting elastases.

Hyung J Chun1, Paul B Yu.   

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Year:  2015        PMID： 26029832      PMCID： PMC4476520          DOI： 10.1164/rccm.201504-0686ED

Source DB:  PubMed          Journal:  Am J Respir Crit Care Med        ISSN： 1073-449X            Impact factor:   21.405


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  15 in total

Review 1.  Therapeutic potential of human elafin.

Authors:  Lee Shaw; Oliver Wiedow
Journal:  Biochem Soc Trans       Date:  2011-10       Impact factor: 5.407

2.  Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence.

Authors:  O Wiedow; J M Schröder; H Gregory; J A Young; E Christophers
Journal:  J Biol Chem       Date:  1990-09-05       Impact factor: 5.157

3.  Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling.

Authors:  Nils P Nickel; Edda Spiekerkoetter; Mingxia Gu; Caiyun G Li; Hai Li; Mark Kaschwich; Isabel Diebold; Jan K Hennigs; Ki-Yoon Kim; Kazuya Miyagawa; Lingli Wang; Aiqin Cao; Silin Sa; Xinguo Jiang; Raymond W Stockstill; Mark R Nicolls; Roham T Zamanian; Richard D Bland; Marlene Rabinovitch
Journal:  Am J Respir Crit Care Med       Date:  2015-06-01       Impact factor: 21.405

4.  Targeted overexpression of elafin protects mice against cardiac dysfunction and mortality following viral myocarditis.

Authors:  S H Zaidi; C C Hui; A Y Cheah; X M You; M Husain; M Rabinovitch
Journal:  J Clin Invest       Date:  1999-04       Impact factor: 14.808

5.  Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival.

Authors:  Tero-Pekka Alastalo; Molong Li; Vinicio de Jesus Perez; David Pham; Hirofumi Sawada; Jordon K Wang; Minna Koskenvuo; Lingli Wang; Bruce A Freeman; Howard Y Chang; Marlene Rabinovitch
Journal:  J Clin Invest       Date:  2011-08-08       Impact factor: 14.808

6.  Regression of hypertrophied rat pulmonary arteries in organ culture is associated with suppression of proteolytic activity, inhibition of tenascin-C, and smooth muscle cell apoptosis.

Authors:  K N Cowan; P L Jones; M Rabinovitch
Journal:  Circ Res       Date:  1999-05-28       Impact factor: 17.367

7.  Monocrotaline-induced cardiopulmonary injury in rats. Modification by the neutrophil elastase inhibitor SC39026.

Authors:  A Molteni; W F Ward; C H Ts'ao; J M Hinz
Journal:  Biochem Pharmacol       Date:  1989-08-01       Impact factor: 5.858

8.  Elafin, a serine elastase inhibitor, attenuates post-cardiac transplant coronary arteriopathy and reduces myocardial necrosis in rabbits afer heterotopic cardiac transplantation.

Authors:  B Cowan; O Baron; J Crack; C Coulber; G J Wilson; M Rabinovitch
Journal:  J Clin Invest       Date:  1996-06-01       Impact factor: 14.808

9.  SC-39026, a serine elastase inhibitor, prevents muscularization of peripheral arteries, suggesting a mechanism of monocrotaline-induced pulmonary hypertension in rats.

Authors:  R Ilkiw; L Todorovich-Hunter; K Maruyama; J Shin; M Rabinovitch
Journal:  Circ Res       Date:  1989-04       Impact factor: 17.367

10.  Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution.

Authors:  M Tsunemi; Y Matsuura; S Sakakibara; Y Katsube
Journal:  Biochemistry       Date:  1996-09-10       Impact factor: 3.162
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  1 in total

1.  Elafin promotes tumour metastasis and attenuates the anti-metastatic effects of erlotinib via binding to EGFR in hepatocellular carcinoma.

Authors:  Chenwei Wang; Yadi Liao; Wei He; Hong Zhang; Dinglan Zuo; Wenwu Liu; Zhiwen Yang; Jiliang Qiu; Yichuan Yuan; Kai Li; Yuanping Zhang; Yongjin Wang; Yunxing Shi; Yuxiong Qiu; Song Gao; Yunfei Yuan; Binkui Li
Journal:  J Exp Clin Cancer Res       Date:  2021-03-26
  1 in total

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