María Lilia López-Narváez1, Carlos Alfonso Tovilla-Zárate2, Thelma Beatriz González-Castro3, Isela Juárez-Rojop4, Sherezada Pool-García5, Alma Genis6, Jorge L Ble-Castillo7, Ana Fresán8. 1. Hospital General de Yajalón, Secretaria de Salud, Yajalón, Chiapas, México. Electronic address: dralilialonar@yahoo.com.mx. 2. Universidad Juárez Autónoma de Tabasco, División Académica Multidisciplinaria de Comalcalco, Comalcalco, Tabasco, México. Electronic address: alfonso_tovillaz@yahoo.com.mx. 3. Universidad Juárez Autónoma de Tabasco, División Académica Multidisciplinaria de Jalpa de Méndez, Cunduacán, Tabasco, México. Electronic address: thelma.glez.castro@gmail.com. 4. Universidad Juárez Autónoma de Tabasco, División Académica de Ciencias de la Salud, Villahermosa, Tabasco, México. Electronic address: iselajua22@yahoo.com.mx. 5. Hospital General de Comalcalco, Tabasco, Secretaría de Salud, Comalcalco, Tabasco, México. Electronic address: shepoga70@hotmail.com. 6. Instituto Nacional de Medicina Genómica (INMEGEN), Servicios de Atención Psiquiátrica (SAP), Secretaría de Salud, México, D. F., México. Electronic address: genis76@yahoo.com. 7. Universidad Juárez Autónoma de Tabasco, División Académica de Ciencias de la Salud, Villahermosa, Tabasco, México. Electronic address: jblecastillo@hotmail.com. 8. Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México, D. F., México. Electronic address: fresan@imp.edu.mx.
Abstract
BACKGROUND: Suicidal behavior is a worldwide health problem. Tryptophan hydroxylase (TPH) is a rate limiting enzyme in the biosynthesis of serotonergic neurotransmission. TPH-1 and TPH-2 genes encode for TPH isoforms and have been implicated as candidate genes for suicidal behavior. The aim of this study was to evaluate the association between the genetic variants of the TPH-1 (rs21102 and 1607395) and TPH-2 (rs4290270, rs7305115 and rs1007023) genes and suicidal behavior in a Mexican population. METHODS: We conducted a case-control study including 200 cases with suicide attempt and 263 controls. Patients were evaluated by a trained psychiatrist or clinical psychologists. Five polymorphisms were genotyped and assessed for allele, genotype and haplotype association with suicide attempt. RESULTS: The rs7305115 polymorphism of the TPH-2 gene was associated with suicidal behavior in a Mexican population in genotype (χ(2)=6.02, df=2, p=0.04) and allele (OR=1.39, 95%IC=1.06-1.81, p=0.01) frequencies. The THP-2 haplotypes GTA (χ(2)=5.68, p=0.01) and ATT (χ(2)=5.0, p=0.02) were associated with risk for suicide attempt. CONCLUSION: Our results provide evidence for an association between the rs7305115 polymorphism of the TPH-2 gene and suicidal behavior in a Mexican population. However, more studies are necessary to replicate these results using larger samples.
BACKGROUND: Suicidal behavior is a worldwide health problem. Tryptophan hydroxylase (TPH) is a rate limiting enzyme in the biosynthesis of serotonergic neurotransmission. TPH-1 and TPH-2 genes encode for TPH isoforms and have been implicated as candidate genes for suicidal behavior. The aim of this study was to evaluate the association between the genetic variants of the TPH-1 (rs21102 and 1607395) and TPH-2 (rs4290270, rs7305115 and rs1007023) genes and suicidal behavior in a Mexican population. METHODS: We conducted a case-control study including 200 cases with suicide attempt and 263 controls. Patients were evaluated by a trained psychiatrist or clinical psychologists. Five polymorphisms were genotyped and assessed for allele, genotype and haplotype association with suicide attempt. RESULTS: The rs7305115 polymorphism of the TPH-2 gene was associated with suicidal behavior in a Mexican population in genotype (χ(2)=6.02, df=2, p=0.04) and allele (OR=1.39, 95%IC=1.06-1.81, p=0.01) frequencies. The THP-2 haplotypes GTA (χ(2)=5.68, p=0.01) and ATT (χ(2)=5.0, p=0.02) were associated with risk for suicide attempt. CONCLUSION: Our results provide evidence for an association between the rs7305115 polymorphism of the TPH-2 gene and suicidal behavior in a Mexican population. However, more studies are necessary to replicate these results using larger samples.
Authors: Jelena Karanović; Maja Ivković; Vladimir M Jovanović; Saša Šviković; Maja Pantović-Stefanović; Miloš Brkušanin; Aleksandar Damjanović; Goran Brajušković; Dušanka Savić-Pavićević Journal: J Neural Transm (Vienna) Date: 2017-01-13 Impact factor: 3.575
Authors: Alma Delia Genis-Mendoza; David Ruiz-Ramos; María Lilia López-Narvaez; Carlos Alfonso Tovilla-Zárate; Ana Rosa García; Gabriela Cortes Meda; José Jaime Martinez-Magaña; Thelma Beatriz González-Castro; Isela Esther Juárez-Rojop; Humberto Nicolini Journal: Brain Behav Date: 2019-06-14 Impact factor: 2.708
Authors: Jadwiga Snarska; Ewa Fiedorowicz; Dominika Rozmus; Konrad Wroński; Maria Latacz; Natalia Kordulewska; Janusz Płomiński; Roman Grzybowski; Huub F J Savelkoul; Elżbieta Kostyra; Anna Cieślińska Journal: BMC Gastroenterol Date: 2021-11-12 Impact factor: 3.067