| Literature DB >> 26028544 |
Jian-Wei Dong1, Le Cai1, Yun-Shan Fang1, Huai Xiao2, Zhen-Jie Li1, Zhong-Tao Ding3.
Abstract
An unusual proaporphine alkaloid bearing an isopropanenitrile group at isoquinoline nitrogen, named epiganine A (1) and a new aporphine alkaloid, epiganine B (2), together with eight known alkaloids, pronuciferine (3), dehydrodicentrine (4), romerine (5), romeline (6), N-methylcalycinine (7), phanostenine (8), dicentrine (9), and N-methyllaurotetanine (10), were isolated from the roots of Stephania epigaea. The absolute configuration of 1 was determined by calculating electronic circular dichroism (ECD) and comparing with experimental data. Compounds 2 and 4 showed strong acetylcholinesterase (AChE) inhibitory effects with the IC50 values of 4.36 and 2.98μM, respectively. Compounds 5-9 also exhibited potent AChE inhibitory activities.Entities:
Keywords: Acetylcholinesterase inhibitory activity; Aporphine alkaloid; Dehydrodicentrine (PubChem CID: 3084326); Dicentrine (PubChem CID: 101300); Epiganine A; Epiganine B; N-methylcalycinine; N-methyllaurotetanine (PubChem CID: 16573); Phanostenine (PubChem CID: 12305138); Proaporphine alkaloid; Pronuciferine (PubChem CID: 200480); Romeline; Romerine (PubChem CID: 119204); Stephania epigaea
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Year: 2015 PMID： 26028544 DOI： 10.1016/j.fitote.2015.05.019
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882