| Literature DB >> 26028498 |
Shirley K Knauer1, Nisintha Mahendrarajah2, Wynand P Roos2, Oliver H Krämer3.
Abstract
The ubiquitin-dependent proteasomal degradation of proteins controls signaling and cellular survival. An increasing body of evidence suggests that the E3 ubiquitin ligases SIAH1 and SIAH2 are able to dictate the growth, development, and chemo-/radiosensitivity of breast and prostate cancer cells. Here we review the current knowledge on the impact of SIAHs on breast and prostate tumorigenesis. Furthermore, we summarize how stress, hormones, and cytokines regulate SIAH1 and SIAH2 in transformed mammalian cells.Entities:
Keywords: Cytokine; Estrogen; SIAH1; SIAH2; Sex hormone
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Year: 2015 PMID： 26028498 DOI： 10.1016/j.cytogfr.2015.04.002
Source DB: PubMed Journal: Cytokine Growth Factor Rev ISSN： 1359-6101 Impact factor: 7.638