| Literature DB >> 26028353 |
Christine Konya1, Ziv Paz2, Sokratis A Apostolidis3, George C Tsokos4.
Abstract
Interleukin 17 is a proinflammatory cytokine produced by CD4+ T cells when in the presence of a distinct set of cytokines and other cells. Preclinical and clinical studies have assigned a role to IL-17 in tissue inflammation and damage in patients with rheumatoid arthritis, psoriasis and psoriatic arthritis, ankylosing spondylitis and systemic lupus erythematosus. Antibodies blocking the action of IL-17 have already been approved to treat patients with psoriasis and it is expected that they may also benefit patients with other rheumatic diseases.Entities:
Keywords: Autoimmune diseases; Biological agents; Interleukin-17
Mesh:
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Year: 2015 PMID: 26028353 DOI: 10.1016/j.cyto.2015.01.003
Source DB: PubMed Journal: Cytokine ISSN: 1043-4666 Impact factor: 3.861